Successful deep brain stimulation treatment of incapacitating tremor resulting from bilateral thalamic infarcts complicating surgery for Arnold Chiari malformation/syringomyelia.
Objective: To describe the clinical features of tremor associated with thalamic infarcts and its treatment with thalamic Deep Brain Stimulation (DBS). Background: Delayed onset involuntary…Novel Programming Strategy to Overcome Loss of Efficacy in Essential Tremor
Objective: A review of programming strategies to maintain tremor suppression adequate for functional satisfaction. Background: Deep brain stimulation (DBS) is FDA approved for Essential tremor since…Astasia, reach and grasp deficits following bilateral medio-dorsal pulvinar lesions
Objective: Analysis of the consequences of bilateral dorso-medial pulvinar lesions Background: Expansion of the dorsal pulvinar in humans and its anatomical connectivity suggests its involvement…Movement disorders in patients with Japanese encephalitis: Experience in a tertiary care hospital in north eastern region of India
Objective: Movement disorders in Japanese encephalitis is known, but under reported. In this study we tried to analyse the spectrum of movement disorders in patients…Effect of intra-striatal 6-OHDA lesion on extra-striatal structures in the mouse
Objective: Characterization of extra-striatal manifestations in the 6-hydroxydopamine (6-OHDA) Parkinson's disease (PD) animal model. Background: PD is a neurodegenerative disorder characterized by progressive loss of…Modulation of thalamocortical network dynamics via deep brain stimulation in humans with Tourette syndrome
Objective: To (1) investigate the impact on thalamocortical network dynamics in response to low frequency and high frequency deep brain stimulation and (2) uncover the…Single unit activity of medial thalamus during goal-directed motor and cognitive behavior in patients with cervical dystonia
Objective: To 1) study neuronal activity of medial thalamic nuclei (MD, CM-Pf) and its role in cognitive and motor human activity and 2) evaluate neuronal…Dopamine reduces Parkinson’s tremor through increased thalamic inhibition
Objective: To identify cerebral mechanisms explaining the effects of dopamine on rest tremor in Parkinson's disease. Background: Resting tremor in Parkinson's disease is related to…Changes of brain structure and cognition in individuals with possible prodromal Parkinson’s disease
Objective: Investigating brain structure and cognition in healthy individuals with positive Parkinson's disease (PD) risk markers (hyposmia, increased hyperechogenic area of the substantia nigra). Background:…Increasing placebo response in Parkinson’s disease through apomorphine pre-conditioning
Objective: To see whether a placebo response requires pharmacological pre-conditioning with apomorphine. Background: Placebos have been found to affect the patient's brain in a number…