Cytokine Profiles as Biomarkers for Neurodegenerative Diseases: An inflammatory study on Parkinson’s Disease and Tauopathies
Objective: To investigate the diagnostic and prognostic value of cytokine profiles in cerebrospinal fluid (CSF) and serum of patients with Parkinson's Disease (PD), Progressive Supranuclear…18F-Florzolotau PET uncovers the Co-pathological Heterogeneity of Tau Protein in Dementia with Lewy Bodies
Objective: We attempted to reveal the topographical deposition patterns of tau proteins in the living brains of patients with DLB in vivo by virtue of…Case Report: An Unusual Case of Corticobasal Syndrome
Objective: To describe a patient with corticobasal syndrome (CBS) and biomarker evidence of multiple proteinopathies. Background: CBS is a clinically heterogeneous syndrome caused by several…A Visual Interpretation Algorithm for Assessing 18F-Florzolotau PET Scans in Progressive Supranuclear Palsy
Objective: This study aimed to develop a visual reading algorithm dedicated to the evaluation of 18F-Florzolotau positron emission tomography (PET) scans in PSP. Background: The…Skin Tau Quantification as a Novel Biomarker in Huntington’s Disease
Objective: To explore skin tau quantification as a potential biomarker for disease severity, motor and cognitive function in Huntington's disease Background: Beyond the aggregation of…7year followup of Asia’s first case of sporadic ATP6AP2 Mutation: α-synucleinopathy or tauopathy?
Objective: ATP6AP2 mutation, previously described in literature to cause early onset Parkinson’s disease (PD) with atypical signs, evolved into frontotemporal lobar degeneration in a 7year…Lingual-Masticatory Myorhythmia and Palatal Tremor as a Presentation of Anti-IgLON5 Disease
Objective: Anti-immunoglobulin-like cell adhesion molecule-5 (anti-IgLON5) disease may manifest with spectrum of various neurological presentations and movement disorders, including prominent sleep movement disorders, bulbar symptoms,…Dermal 4R-Tau seeding as a novel biomarker for Progressive Supranuclear Palsy
Objective: To ascertain the presence of misfolded tau species in the skin of Progressive Supranuclear Palsy (PSP) patients and evaluate its utility as a potential…Is cathepsin D a good target for therapy in Tau-related conditions?
Objective: To study the involvement of cathepsin D in the pathogenesis of Tau-related conditions. Background: The endo-lysosomal system (ELS) is central in processing of neurodegenerative…Tau Deposition in Locus Coeruleus is Associated with Rapid Eye Movement Sleep Behavior Disorder in Progressive Supranuclear Palsy.
Objective: In this study, we aimed to investigate the frequency of Rapid eye movement sleep behavior disorder (RBD) occurring in a large cohort of PSP,…
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