Dorsolateral nigral hyperintensity on 3.0 tesla susceptibility-weighted imaging in idiopathic rapid eye movement sleep behaviour disorder
Objective: To assess the loss of dorsolateral nigral hypersensitivity (DNH), which seems to correspond to nigrosome-1, using susceptibility-weighted imaging (SWI) at 3.0 Tesla (T) in…Alpha-synuclein aggregates of cardiac sympathetic nerves in synucleinopathies and in neurologically unimpaired subjects. Correlation with sympathetic denervation
Objective: To study the cardiac sympathetic innervation and its relationship with the incidence of alpha-synuclein deposits in heart tissue of synucleinopathies and asymptomatic control patients.…Novel PET Tracers of alpha-synuclein for the diagnosis of Parkinson’s disease
Objective: The aim of our project is to develop small molecular weight compounds (Morphomers™) which bind selectively to alpha-synuclein (aSyn) aggregates, in order to generate…Sleep disordered breathing in patients of Parkinson’s disease with REM sleep behavior disorder
Objective: This prospective study was done to study the frequency and pattern of sleep disordered breathing (SDB) in patients with PD with RBD. Background: Parkinson's…Probable REM sleep behaviour disorder and detrusor overactivity in primary cervical dystonia- A case report
Objective: To report two atypical associations of pRBD and DO we came across with a case of primary cervical dystonia. Background: RBD (REM sleep Behaviour…Parkinson’s disease and the frequent reasons for emergency admission in Metropolitan Medical Center; a 2 year retrospective study
Objective: To determine the frequent cause of hospitalization among adult patients with Parkinson's disease (PD) in our institution. Background: Parkinson's disease is the second most…Colonic α-synuclein: A potential diagnostic biomarker in Parkinson’s disease
Objective: To validate detection of α-synuclein pathology in the gastrointestinal (GI) tract as a diagnostic marker of Parkinson's disease (PD). Background: α-synuclein (ASN) deposition in…Unconventional chaperone inhibits alpha-synuclein amyloid formation by promoting off-pathway aggregation
Objective: To find new potential druggable targets that prevent alpha-synuclein aggregation and toxicity in Parkinson's disease. Background: Alpha-synuclein (aS) is the primary protein deposited in…Factors affecting the cardiac sympathetic denervation in autopsy confirmed dementia with Lewy bodies
Objective: To examine the relation among degeneration of the cardiac sympathetic nerve (CSN), clinical features and neuropathological findings in dementia with Lewy bodies (DLB). Background:…Pre-formed fibrils injection worsen pathology caused by AAV-mediated over expression of α-synuclein
Objective: The overall goal is to produce a rat model of Parkinson's disease (PD), which reproduces progressive pathological changes, while displaying profound neuronal cell loss…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.