Glatiramir acetate (Copaxone) causes restoration of the striatal dopamine in a progressive MPTP mouse model of Parkinson’s disease
Objective: To assess if a microglial modulator, Glatiramer Acetate (GA), can restore loss of striatal dopamine (DA) and behavioral deficits following progressive 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)…Exploring therapeutic viability of a non-dopaminergic target for Parkinson’s disease
Objective: Non-dopaminergic protein drug targets are of high interest to develop adjuvant treatments for currently insufficiently addressed symptoms of PD. RGS4, a regulator of G-protein…Vagus nerve stimulation as a novel treatment strategy for Parkinson’s disease
Objective: To assess the therapeutic potential of chronic vagus nerve stimulation (VNS) to attenuate the behavioral and neuronal deficits observed in Parkinson's disease (PD) by…Diffusion tensor imaging biomarkers of nigrostriatal neurodegeneration in early Parkinson’s disease
Objective: Identify magnetic resonance imaging (MRI) biomarkers of nigrostriatal neurodegeneration in early-stage drug-naïve Parkinson's disease (PD). Background: Diffusion tensor imaging (DTI) is an MRI technique…The study of clinical outcome of deep brain stimulation for the idiopathic Parkinson’s disease at 6 months follow-up
Objective: The aim of this study was to assess the motor and psychiatric outcomes at 6 months after subthalamic nucleus deep brain stimulation (STN-DBS) in…Dorsolateral nigral hyperintensity on 3.0 tesla susceptibility-weighted imaging in idiopathic rapid eye movement sleep behaviour disorder
Objective: To assess the loss of dorsolateral nigral hypersensitivity (DNH), which seems to correspond to nigrosome-1, using susceptibility-weighted imaging (SWI) at 3.0 Tesla (T) in…May substantia nigra volume asymmetry be an indicator of motor asymmetry in Parkinson’s disease? A retrospective analysis
Objective: We investigated whether smaller substantia nigra is associated with worse parkinsonism on the corresponding contralateral side. Background: Degeneration of dopaminergic cells and morphologic changes…Transcranial sonography of the substantia nigra and its correlation with iron metabolism and c-reactive protein in Parkinson’s disease
Objective: To measure the echogenicity of the substantia nigra (SN) by transcranial sonography (TCS) in PD patients and discuss its correlation with iron metabolism and…Prognostic factors of motor symptoms in Parkinson’s disease using neuromelanin imaging and the relationship with (123)I-FP-CIT-SPECT
Objective: This study aimed to examine the relationship between findings of neuromelanin sensitive MRI findings and motor complications. We also examined the correlation of findings…Diagnostic value of a new coronal examination plane in transcranial nigral sonography and of additional M-mode tremor frequency determination for the differentiation of idiopathic Parkinson’s disease and essential tremor
Objective: To (1) evaluate a new coronal examination plane in comparison to the established axial examination plane for detection of nigral hyperechogenicity and (2) to…
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