A novel peptide reduces α-synuclein levels and neurodegeneration in cell, invertebrate, and mammalian models of Parkinson’s disease
Objective: To identify and test the effectiveness of a novel peptide to reduce α-synuclein levels and neurodegeneration in cell and animal models of Parkinson’s disease…Diagnostic value of vagus nerve ultrasound in Parkinson’s disease
Objective: To detect by the ultrasound (US) the possible presence of vagus nerve atrophy in patients with PD and its relation to severity of motor,…The clinical significance of the swallow tail sign in distinguishing Parkinson’s disease patients from healthy individuals
Objective: To investigate whether the absence of the swallow tail sign can be applied for distinguishing PD patients from healthy individuals. Background: With conventional MRI,…Iron Imaging as a Diagnostic Tool for Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: We performed a systematic meta-analysis of SN iron imaging studies in PD to better understand the role of iron-sensitive MRI quantification to distinguish patients…Regional free-water differentially associated with glial activation, neuroinflammation, and neurodegeneration in de novo Parkinson’s disease
Objective: Assess to what extent free-water(FW) as measured by diffusion-weighted MRI(dMRI) is a neuroimaging marker of glial activation, neuroinflammation, and neurodegeneration in de novo Parkinson’s disease(PD) patients from…Neurosonography of substantia nigra in patients with isolated essential tremor and in association with Parkinson’s disease of the family nature
Objective: To identify differential clinical and neurosonographic criteria for ET and PD in patients with familial ET. Background: ET and PD are common disorders, especially…Transcranial sonography in HIV infection: Does it reflect infectious and neurological symptoms?
Objective: To study whether transcranial sonography of brain parenchyma shows features with a potential association with clinical and neurological variables in human immunodeficiency virus (HIV)…Substantianigral involvement on Tc99mDaTSPECT-a novel and under recognised imaging finding in Parkinsonian Disorders
Objective: To assess feasibility of identifying SN involvement on DaTi, correlate with laterality of motor symptoms and compare with loss of nigrosome-1 hyperintensity on SWI . Background:…Targeted deep sequencing of brain DNA for detection of somatic point mutations in synucleinopathies
Objective: To detect relevant somatic "point mutations" (single nucleotide variants- SNVs) in brain-derived DNA in synucleinopathies. Background: There is increasing recognition that neurons may harbour…Sequencing of single human nigral dopaminergic neurons for somatic copy number variants
Objective: To detect somatic DNA copy number variants (CNVs) in dopaminergic neurons isolated from human substantia nigra, using shallow whole genome sequencing (WGS). Background: Somatic…
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