Neuropathological profile of tauopathy in spinocerebellar ataxia type 8
Objective: The purpose of this study is to examine the distribution of tau pathology in brain regions of patients with spinocerebellar ataxia type 8 (SCA8).…Visual Hallucinations and Parkinson’s Disease Neuropathology among Decedents with and without Parkinson’s Disease or Lewy Body Dementia During Life
Objective: The purpose of this report is to examine the association between visual hallucinations during life and substantia nigra (SN) neuron density and Lewy pathology…STN-DBS Targeting SNr Modulates Sleep in Parkinson’s Disease: A Proof-of-Concept Study
Objective: To explore how subthalamic deep brain stimulation (STN-DBS) targeting substantia nigra pars reticulata (SNr) can modulate sleep in Parkinson’s disease (PD) patients with electrophysiologic…Genome-wide meta-analysis of Parkinson’s disease identifies a novel chromosomal 22 locus: findings from the COURAGE-PD consortium
Objective: The present study aims to conduct a meta-analysis in a large, diverse cohort to discover novel Parkinson’s disease (PD) loci and replicate previously reported…Gait abnormalities relate to increased extracellular water in the substantia nigra in Parkinson’s disease patients
Objective: The aim of this study was to investigate the role of substantia nigra microstructural integrity in parkinsonian gait impairments. Background: Gait impairments are common…Is Generalized and Segmental Dystonia Accompanied by Impairments of the Dopaminergic System?
Objective: To investigate functional dopaminergic impairments in dystonia, we compared patients with dystonia and Parkinson’s disease (PD) with normal controls using neuromelanin-sensitive magnetic resonance imaging…The evaluation of the swallow tail sign in patients with parkinsonism or gait disorders
Objective: The goal of the study is to evaluate the reliability of swallow tail sign which claimed to be specific for Parkinson's disease. Background: Swallow…Increased free-water in the substantia nigra in idiopathic REM sleep behaviour disorder
Objective: In this study, we tested the hypothesis that free water is elevated in the posterior substantia nigra of idiopathic rapid eye movement sleep behaviour…GBA Mutation Accumulates Higher Alpha-Synuclein in Alpha-Synucleinopathies
Objective: To investigate whether post-translational modifications of α-synuclein will give rise to species that differ between PD cases with N370S GBA mutation and WT-PD. Background:…Iron Imaging as a Diagnostic Tool for Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: We performed a systematic meta-analysis of SN iron imaging studies in PD to better understand the role of iron-sensitive MRI quantification to distinguish patients…
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