Andrograholide protect microglial activation via inhibiting mitochondrial ROS generation and NLRP3 inflammasome activation in in-vitro and in-vivo model of Parkinson’s disease
Objective: Parkinson's disease (PD) is a distressing neurodegenerative disorder effecting nearly 2-3% of the total population greater than 65 years old . Several mechanisms have…A single nigral injection of human ENGRAILED-1 induces long-lasting behavior benefit in an experimental primate model of Parkinson Disease
Objective: Evaluate the efficacy of a single nigral injection of human ENGRAILED-1 (hEN1) in a recognized chronic MPTP macaque model. Background: EN1 homeoprotein has been…Assessment of neuronal morphology to determine the differential susceptibility to Parkinson’s disease using MPTP in two genetically distinct mice strains
Objective: To delineate the contribution of neuronal-dendritic structure in the substantia nigra and striatum, in conferring differential susceptibility to Parkinson’s disease, using two genetically distinct…Neuroprotective actions of red propolis extract and formononetin in a rat model of Parkinson’s disease
Objective: To evaluate the effects of the hydroalcoholic extract of red propolis (HERP) and one of its major compounds, formononetin (FN), against the motor symptoms…Micro structural Changes in Substantia Nigra are associated with Severity of Parkinson’s Disease.
Objective: The aim of this study was to apply diffusion tensor imaging (DTI) to evaluate atrophy of the Substantia Nigra pars compacta (SNc), the pathological…Substantia Nigra (SN) Hyperechogenicity as seen in Transcranial Sonography (TCS) is a reliable disease progression marker from Stage I to Stage II in Early Onset Parkinson’s Disease (EOPD)
Objective: To test the hypothesis that SN hyperechogenicity seen in transcranial sonography (TCS) can be used as a reliable disease progression marker from stage I…Ginsenoside Rb1 protects dopaminergic neurons through Foxm1-Nurr1 pathway in mice model of Parkinson’s disease
Objective: In the present work, we investigated the protective effects of ginsenoside Rb1 in dopaminergic neurons through Foxm1-Nurr1 pathway in mice model of Parkinson’s disease.…The role of substantia nigra sonography in the differentiation of Parkinson’s disease and multiple system atrophy
Objective: To evaluate the differential diagnosis value of transcranial sonography (TCS) between Parkinson’s disease (PD) and multiple system atrophy (MSA) Background: The differential diagnosis of…Neurohormetic properties of mild physical stress against Parkinson’s disease phenotype
Objective: To test whether routine mild physical stress acts as a hormetic strategy against Parkinsonian symptoms among mice. Background: Regular physical exercise is suggested to…Neuromelanin sensitive MRI of substantia nigra: An imaging biomarker to differentiate essential tremor from tremor-dominant Parkinson’s disease
Objective: We aimed to evaluate whether neuromelanin sensitive MRI (NM-MRI) features in the substantia nigra pars compacta(SNc) were of diagnostic value to differentiate untreated ET…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.