The efficacy of quantitative 99mTc-TRODAT-1 SPECT in diagnosis of aged patients with Parkinson’s disease
Objective: We aim to establish the normal reference with quantitative 99mTc-Trodat-1 (TRODAT) SPECT and verify the diagnostic performance in aged Parkinson's disease (PD) patients. Background:…Deep brain stimulation of the globus pallidus interna improves performance in complex oculomotor tasks
Objective: To compare and contrast the effects of deep brain stimulation of (a) the subthalamic nucleus and (b) the globus pallidus interna on advanced Parkinson's…Impairment of decision-making processes in patients with Parkinson’s disease during a strategic game
Objective: To characterize differences in choice patterns, and differentiate the effects of dopaminergic (DA) treatment on motor and cognitive function, during dynamic decision-making in Parkinson's…Polyethylenimine (PEI) nanoparticle-mediated delivery of siRNA to silence neuronal gene expression of alpha-synuclein in a mouse model of Parkinson’s disease
Objective: To develop novel therapeutic strategies for movement disorders by interfering with neuronal gene expression, PEI nanoparticle-mediated delivery of RNA was investigated in vivo. Background:…Striatal and pedunculopontine nucleus diffusion tensor imaging in cervical dystonia
Objective: To characterize white matter integrity in the striatum and pedunculopontine nucleus (PPN) in patients with cervical dystonia using diffusion tensor imaging (DTI). Background: The…Vascular degeneration in Parkinson’s disease
Objective: To determine the role vascular degeneration in human Parkinson's disease (PD). Background: We have previously reported endothelial degeneration in the PD. Current study examined…Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia
Objective: To evaluate the role of the atypical vesicular glutamate transporter 3 (VGLUT3) and the vesicular acetylcholine transporter (VAChT) in L-DOPA-induced dyskinesia. Background: Parkinson's disease…Glatiramir acetate (Copaxone) causes restoration of the striatal dopamine in a progressive MPTP mouse model of Parkinson’s disease
Objective: To assess if a microglial modulator, Glatiramer Acetate (GA), can restore loss of striatal dopamine (DA) and behavioral deficits following progressive 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)…Hydrogen sulfide functions as a neuromodulator to regulate striatal neurotransmission in a mouse model of Parkinson’s disease
Objective: To Evaluate:prepared a MPTP/p induced mouse subacute model of PD, and explore the modulatory effect of H2S on monoamine and amino acid neurotransmitters in…The kinase Fyn mediates levodopa induced dyskinesias in Parkinson´s disease
Objective: To pharmacologically manipulate the kinase Fyn as a novel target to control levodopa induced dyskinesias. Background: The management of levodopa induced dyskinesias (LID) in…
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