Mild mitochondrial impairment promotes corticostriatal synaptic plasticity alterations in PINK1 heterozygous knockout mice
Objective: To investigate the effects of the exposure to low-dose rotenone of heterozygous PINK1 knockout (PINK1+/-) mice, compared to their wild-type littermates (PINK1+/+), on dopamine-dependent…Combined imaging markers increase accuracy when predicting real life disease onset in Huntington’s disease
Objective: To identify a robust imaging marker that is capable of predicting real life disease onset in Huntington's disease (HD). Background: Huntington's disease (HD) is…Neuroprotective potential of L-theanine against excitotoxic neuronal death induced by quinolinic acid: Possible neurotransmitters and nitric oxide modulation mechanism
Objective: To evaluate the neuroprotective efficacy of L-theanine, an unique amino acid with neuroprotective properties, for its beneficial potential if any, in quinolinic acid induced…Tau dysfunction in the basal ganglia of a mouse model of tauopathy related to PSP
Objective: Determine motor coordination and neurochemical phenotypes in the basal ganglia of mice lacking the Tau protein or expressing an abnormal content of Tau isoforms.…Dysregulations of GABAergic neurotransmission in Huntington’s disease brain
Objective: To investigate (1) the expression of GABAA receptors and KCC2 in both Huntington's disease (HD) mouse models and patients and (2) the inhibitory effect…Association between clinical features and pre- and post-synaptic dopaminergic dysfunction in multiple system atrophy: [18F]-FP-CIT PET and [18F]-FDG PET analyses
Objective: To investigate the correlation between clinical features and pre- and post-synaptic dopaminergic dysfunction in patients with multiple system atrophy (MSA). Background: Multiple system atrophy…Motor subtypes in Parkinson’s disease are distinguished by alterations in morphology and white matter integrity
Objective: This study aimed to extend current knowledge on symptomatic heterogeneity in Parkinson's disease (PD) by investigating structural alterations underpinning FC. Background: The postural instability…Relationship between cognitive functions and striatal 123I-FP-CIT uptake in Parkinson’s disease
Objective: We performed cognitive function tests and dopamine transporter (DAT) SPECT in patients with PD (Parkinson's disease) to see whether there is a relationship between…The efficacy of quantitative 99mTc-TRODAT-1 SPECT in diagnosis of aged patients with Parkinson’s disease
Objective: We aim to establish the normal reference with quantitative 99mTc-Trodat-1 (TRODAT) SPECT and verify the diagnostic performance in aged Parkinson's disease (PD) patients. Background:…Deep brain stimulation of the globus pallidus interna improves performance in complex oculomotor tasks
Objective: To compare and contrast the effects of deep brain stimulation of (a) the subthalamic nucleus and (b) the globus pallidus interna on advanced Parkinson's…
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