Regulation of aberrant striatal oscillations by glutamate receptor blockade in parkinsonian non-human primates
Objective: To study the abnormal striatal oscillations and regulation of striatal oscillatory activities by micro-infusion of glutamate receptor antagonist in the non-human primate model of…Semi-automated MRI algorithm using susceptibility weighted imaging for differentiating multiple system atrophy with parkinsonism from Parkinson Disease
Objective: To investigate the diagnostic value of semi-automated diagnostic algorithm using 3T-MR susceptibility-weighted image (SWI) for multiple system atrophy with parkinsonism (MSA-p). Background: Iron deposition…Quantifying reinforcement learning deficits in early stage Parkinson’s patients using a strategic decision-making task
Objective: 1.Characterize deficits in reinforcement learning processes in PD during a strategic game analogous to Rock-Paper-Scissors (RPS). 2.Examine the effects of dopaminergic (DA) treatment on…Motor stress elicits dystonia-like movements in a pharmacological mouse model for Rapid-Onset Dystonia-Parkinsonism (DYT12)
Objective: To study if a mild stressful trigger by motor activity leads to development of dystonia-like movements in a pharmacological mouse model for DYT12. Background:…Striatal Cholinergic Neurons in Cervical Dystonia
Objective: To determine if there is cholinergic neuronal loss in the putamen in cervical dystonia. Background: The etiology of cervical dystonia is unknown. Striatal cholinergic…Longitudinal comparison of 11C-PE2I and 18F-DOPA PET for assessing severity and rate of disease progression in patients with Parkinson’s disease
Objective: To directly compare 18F-DOPA with a highly specific dopamine transporter radioligand 11C-PE2I, for the assessment of motor severity and rate of progression in Parkinson's…Serotonin–to–dopamine transporter ratios in Parkinson’s dyskinesias: the longitudinal study
Objective: This study was designed to detect whether in Parkinson’s disease (PD) the putaminal serotonin–over–dopamine transporter ratio has a threshold that is critical for the…Persistent L-Dopa Responsive Hemiparkinsonism After Cryptococcoal Meningoencephalitis in an Immunocompetent Man
Objective: Our objective is to report a case of persistent L-dopa responsive hemiparkinsonism after Cryptococcal meningoencephalitis in an immunocompetent man. Background: Fungal infections of the CNS are…Polyethylenimine (PEI) nanoparticle-mediated delivery of siRNA to silence neuronal gene expression of alpha-synuclein in a mouse model of Parkinson’s disease
Objective: To develop novel therapeutic strategies for movement disorders by interfering with neuronal gene expression, PEI nanoparticle-mediated delivery of RNA was investigated in vivo. Background:…Striatal and pedunculopontine nucleus diffusion tensor imaging in cervical dystonia
Objective: To characterize white matter integrity in the striatum and pedunculopontine nucleus (PPN) in patients with cervical dystonia using diffusion tensor imaging (DTI). Background: The…
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