Persistent L-Dopa Responsive Hemiparkinsonism After Cryptococcoal Meningoencephalitis in an Immunocompetent Man
Objective: Our objective is to report a case of persistent L-dopa responsive hemiparkinsonism after Cryptococcal meningoencephalitis in an immunocompetent man. Background: Fungal infections of the CNS are…Fluvoxamine maleate normalizes striatal neuronal inflammatory cytokine activity in a Parkinsonian rat model associated with depression
Objective: The objective of this study was to investigate how fluvoxamine maleate treatment regulates depressive-like symptoms, motor impairments and the expressions of IL-1beta, IL-6, IL-10…A whole brain anatomical network model and its application in PD research
Objective: To build a frame of whole brain anatomical network for incorporating different data from different studies with different brain parcellations and resolutions, to evaluate…Dissecting the molecular mechanisms of Fyn-mediated levodopa induced dyskinesias
Objective: To investigate the crosstalk between D1 receptor (D1R) and the signaling of Fyn protein kinase in a mice model of levodopa (L-DOPA) induced dyskinesias…Role of dopamine and GABA during subthalamic and pallidal deep brain stimulation: Evidence of dopamine release during subthalamic Deep Brain Stimulation
Objective: We recorded the single-unit activity of striatal cholinergic interneurons of healthy monkeys during high-frequency stimulation (HFS) of the subthalamic nucleus (STN) and globus pallidus…Vagus nerve stimulation as a novel treatment strategy for Parkinson’s disease
Objective: To assess the therapeutic potential of chronic vagus nerve stimulation (VNS) to attenuate the behavioral and neuronal deficits observed in Parkinson's disease (PD) by…Diffusion tensor imaging biomarkers of nigrostriatal neurodegeneration in early Parkinson’s disease
Objective: Identify magnetic resonance imaging (MRI) biomarkers of nigrostriatal neurodegeneration in early-stage drug-naïve Parkinson's disease (PD). Background: Diffusion tensor imaging (DTI) is an MRI technique…Mild mitochondrial impairment promotes corticostriatal synaptic plasticity alterations in PINK1 heterozygous knockout mice
Objective: To investigate the effects of the exposure to low-dose rotenone of heterozygous PINK1 knockout (PINK1+/-) mice, compared to their wild-type littermates (PINK1+/+), on dopamine-dependent…Combined imaging markers increase accuracy when predicting real life disease onset in Huntington’s disease
Objective: To identify a robust imaging marker that is capable of predicting real life disease onset in Huntington's disease (HD). Background: Huntington's disease (HD) is…Neuroprotective potential of L-theanine against excitotoxic neuronal death induced by quinolinic acid: Possible neurotransmitters and nitric oxide modulation mechanism
Objective: To evaluate the neuroprotective efficacy of L-theanine, an unique amino acid with neuroprotective properties, for its beneficial potential if any, in quinolinic acid induced…
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