Longitudinal comparison of 11C-PE2I and 18F-DOPA PET for assessing severity and rate of disease progression in patients with Parkinson’s disease
Objective: To directly compare 18F-DOPA with a highly specific dopamine transporter radioligand 11C-PE2I, for the assessment of motor severity and rate of progression in Parkinson's…Serotonin–to–dopamine transporter ratios in Parkinson’s dyskinesias: the longitudinal study
Objective: This study was designed to detect whether in Parkinson’s disease (PD) the putaminal serotonin–over–dopamine transporter ratio has a threshold that is critical for the…Persistent L-Dopa Responsive Hemiparkinsonism After Cryptococcoal Meningoencephalitis in an Immunocompetent Man
Objective: Our objective is to report a case of persistent L-dopa responsive hemiparkinsonism after Cryptococcal meningoencephalitis in an immunocompetent man. Background: Fungal infections of the CNS are…Fluvoxamine maleate normalizes striatal neuronal inflammatory cytokine activity in a Parkinsonian rat model associated with depression
Objective: The objective of this study was to investigate how fluvoxamine maleate treatment regulates depressive-like symptoms, motor impairments and the expressions of IL-1beta, IL-6, IL-10…Baseline multimodal information predicts future motor impairment in premanifest Huntington’s disease
Objective: To evaluate the prognostic accuracy of structural magnetic resonance imaging and genetic-based measures in premanifest Huntington’s disease for estimating future motor impairment. Background: Despite…Regulation of aberrant striatal oscillations by glutamate receptor blockade in parkinsonian non-human primates
Objective: To study the abnormal striatal oscillations and regulation of striatal oscillatory activities by micro-infusion of glutamate receptor antagonist in the non-human primate model of…Semi-automated MRI algorithm using susceptibility weighted imaging for differentiating multiple system atrophy with parkinsonism from Parkinson Disease
Objective: To investigate the diagnostic value of semi-automated diagnostic algorithm using 3T-MR susceptibility-weighted image (SWI) for multiple system atrophy with parkinsonism (MSA-p). Background: Iron deposition…Quantifying reinforcement learning deficits in early stage Parkinson’s patients using a strategic decision-making task
Objective: 1.Characterize deficits in reinforcement learning processes in PD during a strategic game analogous to Rock-Paper-Scissors (RPS). 2.Examine the effects of dopaminergic (DA) treatment on…Diffusion tensor imaging biomarkers of nigrostriatal neurodegeneration in early Parkinson’s disease
Objective: Identify magnetic resonance imaging (MRI) biomarkers of nigrostriatal neurodegeneration in early-stage drug-naïve Parkinson's disease (PD). Background: Diffusion tensor imaging (DTI) is an MRI technique…Mild mitochondrial impairment promotes corticostriatal synaptic plasticity alterations in PINK1 heterozygous knockout mice
Objective: To investigate the effects of the exposure to low-dose rotenone of heterozygous PINK1 knockout (PINK1+/-) mice, compared to their wild-type littermates (PINK1+/+), on dopamine-dependent…
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