Effect of Post-Operative Symptomatic Lead Edema Associated with Subthalamic Deep Brain Stimulation On Clinical Outcomes
Objective: To assess whether development of post-operative symptomatic edema around deep brain stimulation (DBS) leads impacts clinical outcomes. Background: Post-operative symptomatic delayed edema around the…Controlled neural organoids grafting promotes functional recovery in experimental parkinsonism
Objective: We propose that the striatal transplantation of 3D-neural organoids of controlled cell size and cell content, named "Controlled Neural Organoids" (CNOs), could circumvent the…Blinded acute assessment of electrode contact efficacy compared with contact location for Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease
Objective: This study aimed to assess the clinical efficacy of each contact and the correlation between the clinical best contacts and radiologically defined optimal contacts.…Modified Frameless Stereotaxy for Gene Therapy in Pediatric Movement Disorder Patients
Objective: We have developed a modified frameless stereotaxic system for viral vector delivery of gene therapy in pediatric movement disorder patients with congenital enzyme deficiency.…Biofabricated tissue constructs to recapitulate the anatomy and functionality of the nigrostriatal pathway in Parkinson’s disease
Objective: 1) Biofabricate constructs that mimic the cytoarchitecture and function of the nigrostriatal pathway, and 2) Microinject constructs to assess restoration of dopaminergic input to…Gamma Knife Radiosurgery for Generalised Dystonia: Is It The Last Part in The Ship of Theseus
Objective: To evaluate the role of radiosurgical thalamotomy in cases of medically refractory generalised dystonia in current era. Background: Gamma knife radiosurgery has been proved…Deep brain recording and surgical time in stereotactic and functional neurosurgery for movement disorders
Objective: To study the impact on the surgical time of the multi-unit recordings (MURs) of deep brain activity in 20 years of movement disrorder neurosurgeries.…Comparison of lead localization in postoperative CT versus MRI
Objective: Evaluation of lead position accuracy may be accomplished by postoperative CT or MRI. Image distortion induced by the lead contacts in MRI question the…First experience with 59 directional leads in deep brain stimulation
Objective: The feasibility of applying new directional leads (D-leads) in standard DBS procedures, possible difficulties or complications were the focus of this study. Background: DBS is…GammaKnife subthalamotomy for Parkinson’s disease
Objective: To assess the feasibility of GammaKnife subthalamotomy in Parkinson's disease Background: Chronic STN stimulation is an established treatment for complicated PD. Bilateral subthalamotomy may…
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