Prevention and management of Deep Brain Stimulation (DBS) surgical site infections (SSI) – multicentre survey of UK practice.
Objective: The aim of this survey was to better understand trends, patterns and practices of DBS surgical site care in the UK. Background: Deep brain…Continuous circadian intracerebroventricular administration of anaerobically preserved dopamine greatly reduces severe L-dopa-related complications in Parkinson’s disease
Objective: We aim to demonstrate the safety and efficacy of continuous circadian intracerebroventricular (i.c.v.) administration of anaerobic-dopamine (A-dopamine) to reduce the L-dopa-related complications (LDRC) in…Intraoperative quantification of MDS-UPDRS tremor measurements using 3D accelerometry
Objective: This study focuses on translating parkinsonian tremor tests to an objective method to rate tremor severity using 3D accelerometry, that can be used during…Impact of rs6265 in the Host and Donor on Dopamine Neuron Graft Function.
Objective: Extend investigations into the effect of the rs6265 single nucleotide polymorphism (SNP) on dopamine (DA) neuron graft efficacy using a parkinsonian rat model. Background:…Magnetic Resonance Image-guided high-intensity focused ultrasound (MRIgFUS) subthalamotomy in Spanish Parkinson’s disease (PD) patients.
Objective: To describe our preliminary results of MRIgFUS subthalamotomy in two PD patients. Background: MRIgFUS thalamotomy has become the preferred surgical approach for refractory essential tremor…Bilateral Magnetic Resonance Imaging-Guided Focused Ultrasound Thalamotomy in Medication-Resistant Essential Tremor Treatment.
Objective: To assess the efficacy and safety of bilateral magnetic resonance imaging-guided focused ultrasound thalamothomy for medication refractory essential tremor in prospective observation of two…Invisible DBS-lead fixation using a patient-specific burr-hole cover
Objective: Deep brain stimulation (DBS) leads need to be securely fixed at the burr-hole after implantation. Commercial devices for this purpose have to be placed…Postural tremors due to a cystic thalamic low-grade glioma treated by stereotactic aspiration
Objective: To describe a rare case of contralateral postural tremors of the upper extremity as the only presenting complaint due to a thalamic solid cystic…Focused Ultrasound Subthalamotomy in Parkinson’s Disease: Lesion Topography and Motor Improvement.
Objective: To describe the topography of unilateral focused ultrasound (FUS) subthalamotomy in Parkinson’s disease (PD), and define correlations between lesion size/location and improvement of cardinal…Evolving inclusion criteria in early manifest Huntington’s disease (HD) to address striatal atrophy: Lessons from HD-GeneTRX-1, the first gene therapy trial
Objective: To describe the early screening experience and evidence-based adaptations to the inclusion criteria for HD-GeneTRX-1 (NCT04120493). Background: AMT-130 is an AAV5-based gene therapy intended…
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