Improved Quantification of DAT-SPECT significantly increases its Performance as an Imaging Biomarker in Parkinson’s Disease
Objective: To investigate potential improvements in signal-to-noise (SNR) derived from advanced image analysis of longitudinal DAT-SPECT data. Background: [123I]Ioflupane SPECT (DAT-SPECT) has been widely used…Dopaminergic denervation and focal motor progression in early Parkinson’s Disease: A 5-year longitudinal study
Objective: To evaluate the progression of posterior putamen dopaminergic denervation in relation to motor progression in the less affected and more affected side of the…Predictive Accuracy of Baseline DaT-SPECT for Freezing of Gait at 5, 7, and 10-year Follow up in The PPMI Cohort
Objective: To see if segmentation models of baseline DaT-SPECT striatal binding ratios (SBR) will predict freezing of gait (FoG) in Parkinson’s Disease over a 5,…Network attack tolerance: A resilience proxy for Parkinson’s disease?
Objective: To investigate if individual capacity in network attack tolerance moderates the relationship between striatal dopamine loss and symptom severity in PD. Background: It was…Diabetes impact on nigrostriatal vulnerability in Parkinson’s Disease
Objective: aim of the study was to investigate whether diabetes mellitus influences nigrostriatal dopaminergic vulnerability in drug-naïve patients with early-stage Parkinson’s Disease (PD). Background: recently,…A 20-Year Follow-Up Case Report with Three DaT-SPECT Scans in Parkinson’s Disease Diagnosis
Objective: To describe a patient who underwent multiple DAT-SPECT scans over a 20-year clinical follow-up period in three distinct clinical settings: a normal scan excluding…Rest Tremor in Parkinson’s Disease Is Associated with Increased Ipsilateral DAT Binding
Objective: To investigate the connection between striatal dopamine transporter binding and cardinal motor symptoms of Parkinson’s disease. Background: The three cardinal motor symptoms of Parkinson’s…Increased free water in the putamen in idiopathic REM sleep behaviour disorder
Objective: This study aimed to evaluate the free water in the dorsoposterior putamen of idiopathic REM sleep behaviour disorder (iRBD) patients, which is considered a…Hemiparkinsonism secondary to a cerebral cavernous malformation (CCM)
Objective: To describe a case of secondary parkinsonism of unhabitual cause and complex treatment. Background: Secondary parkinsonism constitutes approximately 15% of all parkinsonism cases in…Neurophysiological markers of motor reserve in Parkinson’s disease
Objective: Our objective was to investigate Motor Reserve (MR) in idiopathic Parkinson’s Disease (PD). Background: MR is defined as the resilience mechanisms of the brain…
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