miRNAs from blood serum as an early diagnostic biomarker for Parkinson’s disease: A study in an animal model
Objective: This work aims to elucidate miRNA-based biomarkers for the early stages of Parkinson`s Disease diagnosis in a chemically induced PD rat model. Background: The…Curcumin prevented electrophysiological and behavioral alterations in a rotenone model of Parkinson’s disease
Objective: This study discusses the in vivo electrophysiology of the hippocampus, behavioral correlates after rotenone intoxication. Background: Parkinson's disease is a progressive nervous system disorder…Evaluation of the anxiolytic effects of naringenin in rotenone-induced rat model of Parkinson’s disease by an elevated plus maze test
Objective: The study was designed to assess the anxiolytic effects of naringenin on rotenone-induced anxiety-like behavior, biochemical and neurochemical alterations. Background: Anxiety is a preclinical…Neuroprotective effects of allicin microemulsion against intrastriatal rotenone and manganese induced Parkinsonism in rats
Objective: Allicin is flavonoid that possess neuroprotective potential but main impediment is its low bioavailability which was improved with microemulsion. The present study was framed…Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease
Objective: Given the presence and function of SRY in male DA (dopamine) neurons, we hypothesised that dysregulation of SRY may contribute to male susceptibility to…Rotenone exposure is associated with mitochondrial DNA (mtDNA) damage in humans
Objective: To determine if mtDNA damage can serve as a biomarker of prior pesticide exposure. Background: Mitochondrial dysfunction is a hallmark of PD, and exposure…Poly-ADP-ribose polymerase 1 modulates mitochondrial fission via LRRK2 in a rotenone-induced Parkinson’s disease model
Objective: To clarity the effects and mechanism of poly-ADP-ribose polymerase 1(PARP1) in regulating mitochondrial fusion/fission in a rotenone-induced Parkinson's disease (PD) model. Background: Accumulating evidences…High repressive activity of olive extracts on the cell line model of Parkinson disease against ROS induction
Objective: Neurodegenerative diseases including Parkinson’s disease (PD) mostly accompany with induction of high ROS in neuronal cells. It is believed that unusual level of ROS…Quercetin administration abrogates the Parkinson’s disease (PD)-like motor and non-motor symptoms and attenuates the behavioral, neurochemical and biochemical deficits induced by rotenone toxicity in rats
Objective: The present study was carried out to investigate the preventive and therapeutic effects of quercetin (a flavonol) against rotenone-induced neurotoxicity. Background: Rotenone (pesticide) induced…Chlorogenic acid and Trianthema portulacastrum combinational therapy mitigates rotenone induced Parkinsonism in wistar rats
Objective: The present study was aimed to explore the synergistic neuroprotective effect of combination of natural phenolic compound, i. e., chlorogenic acid, and butanol extract…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.