Preclinical Studies: Investigating Serum-Based Exosomal miRNAs in Prodromal Drug-Induced Parkinson’s Disease
Objective: This work aims to elucidate the identification of homologs of miRNAs in a pronormal stage of Parkinson`s disease. Background: Parkinson's disease (PD) is defined…Deciphering the Role of Auranofin-Loaded Nanoparticles Against Rotenone Model of Parkinson’s Disease: Via GSK-3β/ Nrf2/HO-1 Signaling Pathways
Objective: To investigate the neuroprotective effect of AUF-loaded nanoparticles in animal models of Parkinson's disease by modulating GSK-3β/ Nrf2/HO-1 Signaling Pathways. Background: Parkinson's disease (PD) is…Consistent downregulation of rarely reported antioxidant genes viz., GGL, TR, TrX, HO-1, GR, GS, in the mid brain regions among mice and Drosophila exposed to Parkinsonian toxins: Scope as early diagnostic markers
Objective: The study aimed at deciphering status of redox genes in mid-brain regions of 2 major in vivo study models: mice/Drosophila melanogaster exposed to Parkinson…The Protective Effect of Sutherlandia frutescens in a Rotenone-Induced Rat Model of Parkinson’s Disease.
Objective: The objective of this study was to investigate the impact of rotenone, a pesticide associated with Parkinson's-like symptoms, and Sutherlandia frutescens (SF), a plant…Manganese-induced Parkinsonism Vs Rotenone-induced Parkinsonism: Animal Life Matters!
Objective: To evaluate the Parkinsonism mimicking potential of MnCl2 in an experimental rat model.To compare the destructive effect of MnCl2 with rotenone by performing behavioral,…Systematic Review and Meta-Analysis of Pesticide Exposure and the Risk of Parkinson’s Disease
Objective: This study aimed to investigate the association between exposure to pesticides and the risk of Parkinson’s disease (PD). Background: PD is the second most…Neuroprotective Effect of Isoquercitrin in Rotenone Induced Parkinson’s Disease-Like Motor and non-motor Symptoms in Zebrafish
Objective: The objective of study is to find out the effect of isoquercitrin, a plant-derived chemical, against Parkinson-like symptoms induced by rotenone in zebrafish.. Background:…The comparison of curcumin and naringenin effects on motor function in rotenone model of Parkinson’s disease
Objective: The aim of the study was to compare the effects of curcumin and naringenin on rotenone-induced motor deficits and related neurochemical changes. Background: Experimental…Role of nanoparticles of berberine on oxidative stress in nigrostriatal tissue and neurobehavioral characteristics in rotenone induced animal model of Parkinson’s disease
Objective: The current study exemplified the therapeutic potential of solid lipid nanoparticles (SLN) of berberine (BE-SLN) against oxidative stress in nigrostriatal tissue and neurobehavioral characteristics…miRNAs from blood serum as an early diagnostic biomarker for Parkinson’s disease: A study in an animal model
Objective: This work aims to elucidate miRNA-based biomarkers for the early stages of Parkinson`s Disease diagnosis in a chemically induced PD rat model. Background: The…
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