Clinical Progression and Genetic Pathways in Body-First and Brain-First Par-kinson’s Disease
Objective: We aim to assess Parkinson's disease (PD) phenotypes across both prodromal and clinical PD stages, track their pathological progression in vivo and identify potential underlying…Sleep-wake Alterations are Associated with a Decreased DTI-ALPS, a Marker of Perivascular Glymphatic Functioning, in Patients with Isolated REM Sleep Behavior Disorder
Objective: We aimed to explore circadian disruption in iRBD and its association with the Diffusion Tensor Imaging- ALong the Perivascular Space (DTI-ALPS) index, a proxy…Color Vision In Patients With Clinical Manifestations Of Rem Sleep Behavior Disorder
Objective: To evaluate the presence of changes in color vision in patients with REM sleep behavior disorder (RBD), Parkinson's disease (PD), and controls. Background: Visual…Eye tracking identifies biomarkers predicting Parkinson’s disease before motor symptom onset
Objective: To investigate eye movement changes as an early motor biomarker of Parkinson’s disease (PD) in patients with REM sleep behavior disorder (RBD). Background: RBD…Plasma Lipids as Potential Biomarkers for Progression of Sleep Disturbances in Parkinson’s Disease
Objective: Determine if plasma lipid levels can serve as a surrogate biomarker of future onset of RBD symptoms or nighttime sleep burden in patients with…Cognitive Decline in Parkinson’s Disease: A Decade-Long Registry Analysis of Prevalence and Risk Factors
Objective: This study aims to identify predictors of cognitive decline in cognitively normal Parkinson’s disease patients by analyzing the 10 years-long PD registry. Background: Cognitive…Pure Autonomic Failure As a Severe “Body-First Subtype” of Lewy Body Disease: A Multimodal Imaging Study of the Autonomic Nervous System
Objective: Using multi-modal imaging this study aimed to characterize the deterioration of the parasympathetic and sympathetic nervous system in pure autonomic failure (PAF) in comparison…Identification of Brain Atrophy Subtypes in Prodromal and Overt Synucleinopathies: A Multicenter Study
Objective: To identify unique subtypes of synucleinopathy with distinct spatiotemporal patterns and trajectories of brain atrophy and disease burden. Background: The synucleinopathies manifest as a…Whole-brain functional network signature reflecting conversion of isolated REM sleep behavior disorder
Objective: The aim was to investigate the brain functional network alteration /pattern as a measure to identify the conversion from idiopathic rapid eye movement sleep…Morphology and Functional Connectivity of the Basolateral Amygdala and Rapid Eye Movement Sleep Behavior Disorder
Objective: To determine the correlation of BLA morphology and functional connectivity (FC) with severity of RBD. Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD)…
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