Dual hit model of Parkinson’s disease propagation using MRI biomarkers and partial least squares path modeling
Objective: This study aimed using multimodal MRI to test two models of Parkinson’s disease propagation and investigated how the models were influenced by the presence…Neuroimaging Extra-Striatal D2 Receptors in Parkinson’s Disease with Rapid Eye Movement Sleep Behaviour Disorder
Objective: Our aim was to characterize the extra-striatal dopamine in Parkinson’s disease (PD) with and without rapid eye movement sleep behaviour disorder (RBD) using in…Autonomic symptoms as biomarkers in REM Sleep Behavior Disorder and Parkinson’s disease
Objective: This study was designed to evaluate autonomic functions in iRBD compared to PD and controls including longitudinal follow-up assessments to evaluate their potential to…RBD and autonomic dysfunction in newly diagnosed Parkinson’s disease patients
Objective: To determine whether newly diagnosed Parkinson’s disease (PD) patients with REM sleep behavior disorder (RBD) are more likely to have symptoms of autonomic dysfunction.…Intestinal transit in early-moderate Parkinson’s disease correlates with probable RBD – subclinical esophageal dysmotility does not correlate
Objective: To investigate esophageal and intestinal transit times in early-moderate Parkinson's disease (PD) and to study correlations with probable RBD and subjective symptoms. Background: Intraneuronal…The clinical features of non-motor symptoms in Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder(RBD)
Objective: To review non-motor symptoms of PD with RBD, To explore the effects of RBD on PD. Background: Non-motor symptoms of PD with RBD were…Spreading ɑ-synuclein pathology initiated from the sublaterodorsal tegmental nucleus models RBD followed by Parkinsonian phenotypes in mice
Objective: To recapitulate ɑ-synucleinopathy based RBD-like behaviors in mice which could further proceed to develop Parkinsonian behavioral and histopathological phenotypes. Background: Idiopathic REM sleep behavior…Parkinson Progression Marker Initiative 2.0 – New Science/New Cohorts
Objective: The Parkinson Progression Marker Initiative 2.0 (PPMI 2.0) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes,…“Brain-first” vs. “body-first” Parkinson’s disease is determined by RBD-status – a multi-modality imaging study
Objective: In a multi-modality imaging study, we test the hypothesis that Parkinson’s disease (PD) can be divided into two strikingly distinct phenotypes: (1) PD patients,…Efficacy and Safety of the 5-Hydroxytryptophan on REM Sleep Behavior Disorder in Parkinson’s Disease.
Objective: To evaluate the efficacy of the 5-HTP on RBD status in patients with Parkinson's disease (PD). Background: REM sleep behavior disorder (RBD) is reported…
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