Ultra-early Diagnosis of MSA-C Using Biological Biomarkers: A Two-Case Study Employing α-Synuclein PET and Fluid α-Synuclein Seeds Amplification Assay (SAA)
Objective: To report cases in which combined α-synuclein PET and body fluid α-synuclein seeds amplification assay (SAA) enabled biological diagnosis of multiple system atrophy–cerebellar type…Metabolic Brain Pattern and Longitudinal Progression in GBA-Associated Parkinson’s Disease Revealed by 18F-FDG PET/CT
Objective: To characterize the cerebral metabolic pattern of GBA-associated Parkinson’s disease (GBA-PD) using 18F-FDG PET/CT and to compare its longitudinal characteristic with genetically undefined Parkinson’s…Comparison of Regional Perfusion Patterns in Clinical Subtypes of PSP and CBD: Dual Phase [¹⁸F]FP CIT PET Study
Objective: To investigate the regional perfusion patterns using PET imaging across various clinical subtypes of PSP and CBD. Background: On MRI, PSP typically shows midbrain…Longitudinal FDG-PET Study of Metabolic Trajectories and Connectivity Alterations in Multiple System Atrophy
Objective: 本研究使用 FDG-PET 探索 MSA 中葡萄糖代谢和网络连接的纵向变化,以辅助早期诊断和监测疾病进展。 Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease with distinct metabolic patterns in its parkinsonian (MSA-P)…Clinical Profile and 18F -Fluorodopa Positron Emission Tomography (18F -DOPA PET) Findings in a Movement Disorder Clinic Patient Cohort
Objective: This study aimed to evaluate the utility of 18F -DOPA PET in patients with diagnostic uncertainty at our movement disorder clinic in India. Background:…PET and Clinical Evidence for Neuroprotective Effects of KM-819 on MSA
Objective: To assess the effect of KM-819 on the progression of multiple system atrophy (MSA). Background: Parkinson’s brain is associated with increased expression of the…Cerebral Glucose Metabolic Features of GBA-Parkinson’s Disease as a window into cognitive impairment
Objective: to investigate cerebral glucose metabolism via fluorodeoxyglucose positron emission tomography (FDG-PET) and its correlation to clinical features in Parkinson’s disease (PD) patients with GBA1…Topographical heterogeneity of cholinergic system status in Multiple System Atrophy: A series report
Objective: To characterize individual-level topographical patterns of cholinergic upregulation and downregulation in Multiple System Atrophy (MSA) using a whole brain voxel-wise approach. Background: MSA is…Uncovering the heterogeneity of spatiotemporal trajectories of neurodegeneration in Parkinson’s disease: an early-phase 18F-FP-CIT PET study
Objective: To define the subtypes of Parkinson’s disease (PD) based on the spatiotemporal progression patterns of cerebral hypoperfusion. Background: Early-phase 18F-FP-CIT PET images, which are…Metabolic Patterns in Multiple System Atrophy: Brain Network Insights from Spatial ICA of FDG-PET
Objective: This study employs spatial independent component analysis (ICA) on 18F-fluorodeoxyglucose (FDG)-PET imaging to decompose metabolic heterogeneity in Multiple system atrophy (MSA), identifying key brain…
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