Evidence of Systemic and Neuro-Inflammation in Progressive Supranuclear Palsy: Insight from an Imaging-Inflammation Study
Objective: To investigate the role of Th17 pathway in systemic and central inflammation in PSP and to identify signatures of inflammation-induced neurodegeneration in PSP. Background:…Distinct FDG PET Metabolic Signatures and Dopaminergic Loss Across Multiple System Atrophy Subtypes
Objective: To delineate subtype‑specific metabolic networks in Multiple system atrophy (MSA) using FDG‑PET, and to examine how these patterns relate to striatal dopamine transporter (DAT)…Role of florzolotau (18F) positron emission tomography in the diagnosis and clinical management of progressive supranuclear palsy: a real-world study
Objective: This study aimed to evaluate the diagnostic utility of florzolotau (18F) positron emission tomography (PET) and its impact on therapeutic decision-making in patients with…Spatial Metabolic Covariance Networks in PSP: Implications for Symptomatology and their Neural Basis
Objective: This study aimed to apply spatial ICA to 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) data from PSP patients and healthy controls (HCs) to identify…Asymptomatic GBA1 Mutation Carriers Have Increased Cortical Cholinergic Activity
Objective: The objective of this study was to assess cholinergic activity changes in patients with Parkinson’s disease carrying GBA1 variants(GBA-PD) and in non-manifesting carriers(GBA-NMC) using…Brain Target Engagement and Pharmacokinetic-Enzyme Occupancy (PK-EO) Relationship of FNP-223: A Novel Oral OGA Inhibitor for Progressive Supranuclear Palsy – Phase 1 PET Study
Objective: To determine the brain O-GlcNAcase (OGA) occupancy, following a single oral dose of FNP-223 (formerly ASN90) and to determine PK-EO relationship. Background: Preclinical evidence…STN-DBS Improves Motor and Cognitive Functions Associated with Increased Occipital Metabolism in PDD Patients
Objective: The study aims to determine whether STN-DBS brings about clinical benefits for Parkinson’s disease dementia (PDD) patients and its association with metabolic change in…Transcutaneous Afferent Patterned Stimulation: A Non-Invasive Approach to Modulate Brain Metabolism in Essential Tremor
Objective: To investigate the mechanism of transcutaneous afferent pattern stimulation (TAPS) using PET imaging to assess brain metabolic changes associated with tremor reduction in individuals…Seed-based Metabolic Networks and Time Series Variation based on Functional [18F]-FDG PET in Parkinson’s Disease
Objective: To analyse seed-based metabolic networks and time series variation in Parkinson’s disease with and without mild cognitive impairment based on functional PET (fPET) Background:…The Cholinergic System in Cervical Dystonia – An [18F]-FEOBV PET study
Objective: To investigate presynaptic cholinergic functioning in cervical dystonia (CD) by comparing [18F]-FEOBV binding in patients and controls, as well as exploring correlations with motor…
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