Interactions between amyloid-β and microglial activation in Parkinson’s disease
Objective: To evaluate the relationship between microglial activation and amyloid-β deposition in the brain using positron emission tomography (PET) in Parkinson’s disease (PD) with normal…The role of phosphodiesterase 4 in sleep disturbances in Parkinson’s disease
Objective: We aimed to assess the association between phosphodiesterase 4 (PDE4) expression and sleep disturbances in vivo using combined multimodal magnetic resonance imaging (MRI) and…Diagnostic utility of regional [18F]AV-1451 tau-PET measurements in PSP
Objective: To determine the diagnostic utility of regional subcortical [18F]AV-1451 tau-PET measurements to differentiate progressive supranuclear palsy (PSP) from age-matched controls and Alzheimer’s dementia patients.…Extrapyramidal involvement in amyotrophic lateral sclerosis: results of a prospective population-based study
Objective: To assess frequency, clinical characteristics and functional neuroimaging correlates of parkinsonian signs in a population-based series of new-diagnosed amyotrophic lateral sclerosis (ALS) patients. Background:…[18F]-AV-1451 binding to neuromelanin in the substantia nigra in PD and PSP
Objective: This study was designed to investigate the binding of [18F]-AV-1451 to neuromelanin in parkinsonisms. Uptake in the substantia nigra of Parkinson’s disease (PD) and…Assessing cholinergic innervation in Parkinson’s disease using the PET imaging marker [18F]Fluoroethoxybenzovesamicol
Objective: To validate [18F]Fluoroethoxybenzovesamicol ([18F]FEOBV) imaging in healthy volunteers by dynamic scanning. The secondary objective of this study was to evaluate the differences in [18F]FEOBV binding…PET-MRI Imaging in Parkinson Dementia Complex of Guam: A Case Report
Objective: To describe the PET-MRI brain and DaTscan findings in a case of Parkinson Dementia Complex of Guam. Background: The indigenous Chamorro people of Guam…Hypometabolism in Orbitofrontal and Perirhinal Cortex is Associated with Impulse Control Disorder in Parkinson´s Disease
Objective: (i)To elucidate the metabolic correlates sub-serving the clinical expression of ICD in PD and (ii) to evaluate the association between the glucose metabolism and…Altered PDE10A Expression Detectable Early in Untreated Parkinson’s Disease Patients
Objective: To investigate in vivo whether loss of PDE10A expression in Parkinson’s disease (PD) is an early phenomenon in early untreated PD patients using positron…Imaging of phosphodiesterase 10 A (PDE10A) enzyme levels in the living human brain of Huntington’s disease gene expansion carriers and healthy controls with positron emission tomography.
Objective: The objective of this study was to examine the loss of Phosphodiesterase 10A enzyme (PDE10A) across a broad spectrum of Huntington’s disease (HD) stages.…
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