[18F]FP-CIT and [18F]FDG PET findings in MSA patients with cognitive impairment
Objective: We investigated the brain dopaminergic system and glucose metabolism in multiple system atrophy (MSA) patients with cognitive impairment. Background: Since the first report of…Study on feasibility to develop a central nervous system (CNS) Leucine-rich repeat kinase 2 (LRRK2) PET tracer
Objective: To assess feasibility of developing a CNS LRRK2 PET tracer. Background: LRRK2 enzyme belongs to the leucine-rich repeat kinase family. Pathogenic mutations in the…18F-FDG PET brain in Parkinsonism
Objective: To determine if 18F-FDG PET can differentiate Parkinson's Disease from Parkinson's-Plus syndromes Background: Parkinsonism is a clinical syndrome of tremor, rigidity, bradykinesia and postural…Alterations of cortical metabotropic glutamate receptor-mediated signaling in patients with Parkinson’s disease
Objective: To evaluate expression of brain metabotropic glutamatergic receptor 5 and the relationship with clinical measures in Parkinson’s disease patients. Background: Metabotropic glutamate receptor 5…Amyloid deposition affects cognitive manifestations in Parkinson’s disease: The PPMI dataset
Objective: To investigate the contribution of amyloid depositions to cognitive deficits in the early phase of Parkinson’s disease (PD). Background: Involvement of amyloid deposits is…Dopaminergic and Metabolic Imaging in Parkinson’s Disease motor subtypes and their relations to parkinsonian tremor
Objective: The mechanism underlying rest tremor of Parkinson’s disease(PD), while likely differing from those underlying akinesia and rigidity, remains unclear. The objective of this study…FDG-PET and metabolomics in PD-associated GBA variants
Objective: To assess the clinical, cognitive, metabolic, and imaging phenotypes of PD patients carrying the variants p.E365K and p.T408M in the GBA gene (NM_000157.3). Background:…L-Dopa Responsiveness is Correlated to Fluorodeoxyglucose Metabolism and Dopamine Transporter Availability in Parkinson’s Disease
Objective: We aim to explore if the degree of l-dopa responsiveness would be correlated to metabolism level in specific brain areas by using 18F-FDG and…Presynaptic dopamine depletion determines the timing of levodopa-induced dyskinesia onset in Parkinson’s disease
Objective: To investigated whether dopaminergic function in the nigrostriatal system is associated with the timing of levodopa-induced dyskinesia (LID) onset in Parkinson's disease (PD). Background:…Amyloid PET and cognition in Parkinson’s disease
Objective: To investigate the relationship between cerebral amyloid accumulation and cognition in Parkinson’s disease (PD). Background: The neuropathology underlying the development of dementia in Parkinson’s…
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