[18F]FP-CIT and [18F]FDG PET findings in MSA patients with cognitive impairment
Objective: We investigated the brain dopaminergic system and glucose metabolism in multiple system atrophy (MSA) patients with cognitive impairment. Background: Since the first report of…Study on feasibility to develop a central nervous system (CNS) Leucine-rich repeat kinase 2 (LRRK2) PET tracer
Objective: To assess feasibility of developing a CNS LRRK2 PET tracer. Background: LRRK2 enzyme belongs to the leucine-rich repeat kinase family. Pathogenic mutations in the…18F-FDG PET brain in Parkinsonism
Objective: To determine if 18F-FDG PET can differentiate Parkinson's Disease from Parkinson's-Plus syndromes Background: Parkinsonism is a clinical syndrome of tremor, rigidity, bradykinesia and postural…Alterations of cortical metabotropic glutamate receptor-mediated signaling in patients with Parkinson’s disease
Objective: To evaluate expression of brain metabotropic glutamatergic receptor 5 and the relationship with clinical measures in Parkinson’s disease patients. Background: Metabotropic glutamate receptor 5…Amyloid deposition affects cognitive manifestations in Parkinson’s disease: The PPMI dataset
Objective: To investigate the contribution of amyloid depositions to cognitive deficits in the early phase of Parkinson’s disease (PD). Background: Involvement of amyloid deposits is…Dopaminergic and Metabolic Imaging in Parkinson’s Disease motor subtypes and their relations to parkinsonian tremor
Objective: The mechanism underlying rest tremor of Parkinson’s disease(PD), while likely differing from those underlying akinesia and rigidity, remains unclear. The objective of this study…FDG-PET and metabolomics in PD-associated GBA variants
Objective: To assess the clinical, cognitive, metabolic, and imaging phenotypes of PD patients carrying the variants p.E365K and p.T408M in the GBA gene (NM_000157.3). Background:…L-Dopa Responsiveness is Correlated to Fluorodeoxyglucose Metabolism and Dopamine Transporter Availability in Parkinson’s Disease
Objective: We aim to explore if the degree of l-dopa responsiveness would be correlated to metabolism level in specific brain areas by using 18F-FDG and…Utility of THK-5351 tau-PET for differential diagnosis in patients with hypokinetic-rigid syndromes.
Objective: The objective of our study is to investigate the use of THK-5351 tau- PET-imaging as an additional tool for differential diagnosis in hypokinetic-rigid syndromes suggestive…Functional role of the cerebellum in Parkinson’s disease : a PET-Study
Objective: The aim of this study is to confirm the hypothesis of a functional involvement of the cerebellum in Parkinson's disease according to a tri-compartmental…
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