Early cognitive impairment is associated with specific regional cholinergic denervation in Parkinson’s disease
Objective: To evaluate regional cholinergic correlates of cognitive impairment in newly diagnosed, treatment-naïve Parkinson’s disease (PD) patients. Background: Mild cognitive impairment (PD-MCI) is a common…Alpha-synuclein preformed fibril (PFF)-triggered synucleinopathy recapitulates neurochemical features of human PD: A PET study in rats
Objective: To investigate longitudinal dopaminergic deficits and similarity to human Parkinson’s disease (PD) using PET imaging in the rat alpha-synuclein (a-syn) preformed fibril (PFF) model.…Gait initiation in patients with Progressive Supranuclear Palsy: a biomechanical and FDG-PET study
Objective: To define the brain metabolic abnormalities related to gait initiation (GI) failure in subjects with Progressive Supranuclear Palsy (PSP). Background: PSP is an atypical…Multiple System Atrophy: phenotypic spectrum approach coupled with brain FDG PET
Objective: This study attempts to identify different phenotypes of patients with MSA and to describe corresponding brain 18-FDG Positron Emission Tomography (PET) patterns. Background: In…Imaging Brain Insulin Resistance in Parkinson’s Disease using [¹⁸F]FDG-PET
Objective: To obtain a glucose brain uptake survey of Parkinson's Disease (PD) patients with or without insulin resistance (IR). Background: IR is common in PD…Potential involvement of the caudate nucleus in GBA-associated Parkinson’s disease
Objective: Multimodal functional assessment of striatocortical loop integrity in Parkinson’s Disease (PD) patients with and without GBA variants Background: Biallelic GBA mutations provoke the lysosomal…Beneficial effect of estrogen on nigrostriatal dopaminergic neurons in drug-naïve postmenopausal Parkinson’s disease
Objective: To investigate the potential beneficial effects of estrogen on nigrostriatal dopaminergic neuron degeneration in postmenopausal drug-naïve Parkinson’s disease. Background: Epidemiologic studies have revealed that…“Brain-first” vs. “body-first” Parkinson’s disease is determined by RBD-status – a multi-modality imaging study
Objective: In a multi-modality imaging study, we test the hypothesis that Parkinson’s disease (PD) can be divided into two strikingly distinct phenotypes: (1) PD patients,…Genotype influences circuit compensation in Parkinson’s disease
Objective: This study investigates differences in brain network organization in patients with Parkinson’s disease (PD) with genetic risk factors relative to sporadic PD patients and…Cortical FDG-PET patterns predict long-term motor progression and disability milestones in Parkinson’s disease
Objective: To evaluate the accuracy of single-subject FDG-PET in predicting motor and cognitive long-term progression in Parkinson's disease Background: The progression of Parkinson's disease is…
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