Visualising tau in patients with progressive supranuclear palsy using PI2620-PET
Objective: This study investigates the use of a new tau-specific PET radiotracer, [18F]-PI-2620, as a tool for visualising tau in the living brain. Background: The…Metabolic patterns and neurodegeneration in isolated REM sleep behavior disorder
Objective: To elucidate the role of Parkinson’s disease (PD)-related brain metabolic patterns as a biomarker in isolated rapid-eye-movement sleep behavior disorder (iRBD) for clinical correlation…Longitudinal 18F-PBR06 (TSPO) and Volumetric MR Imaging as Pharmacodynamic Endpoints for MSA – Ongoing Investigator Sponsored Trial of Verdiperstat
Objective: In multiple system atrophy (MSA) patients to: 1) evaluate 18F-PBR06 positron emission tomography (PET) for longitudinal assessment of 18-kilodalton-translocator protein (TSPO) binding; 2) assess…Persistent and efficient transduction of the putamen following gene therapy for aromatic L-amino acid decarboxylase deficiency
Objective: This study aimed to evaluate longitudinal transduction in subcortical regions and transduction of the cortico-putaminal network after putaminal AADC gene therapy. Background: Aromatic L-amino…Language impairment in Corticobasal Syndrome: from clinical phenotype to biomarkers
Objective: To investigate the language impairment profile of patients diagnosed as probable Corticobasal Syndrome (CBS) [1] in light of a multimodal imaging biomarkers analysis, namely…Lateralized Tau Pathology in a Case of Lewy Body Dementia with Corticobasal Syndrome
Objective: To measure bilateral in vivo and postmortem tau pathology in a well-characterized patient presenting with corticobasal syndrome (CBS) due to underlying neocortical stage Lewy…Cognitive reserve in non-demented patients with Parkinson’s disease might protect against amyloid burden effect on cognition
Objective: To evaluate the effect of cognitive reserve (CR) in patients with Parkinson’s disease (PD) without dementia. Background: CR concept is a principal factor explaining…Striatal dopaminergic loss in early clinically unilateral Parkinson’s disease: a systematic review
Objective: To quantify the extent of dopaminergic loss in early clinically unilateral PD from studies using presynaptic dopamine imaging with either single photon emission computed tomography…Insulin resistance and Parkinson’s disease
Objective: To investigate peripheral insulin resistance and cerebral FDG-PET changes in Parkinson’s disease (PD). Background: Glycated hemoglobin levels (HbA1c) is used as a marker of…The usefulness of a dual-phase 18-F-FP-CIT PET in a case of Alzheimer’s disease with slow movement
Objective: To think about the usefulness of a dual-phase 18-F-FP-CIT PET in cases of dementia with bradykinesia. Background: A classic 18-F-FP-CIT PET is useful in…
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