Clinical variants of PSP: phenotypical convergence and its relationship with the brain glucose metabolism
Objective: To evaluate the phenotypical convergence phenomena among a cohort of different PSP variants. We also aimed to evaluate the possible correlations of the regional…Progression of neuroinflammation in patients with isolated REM sleep behavior disorder. A 11C-PK11195 PET study
Objective: The aim of this study was to investigate in vivo the progression of neuroinflammation iRBD patients over a 3-year follow-up. Background: Isolated rapid-eye-movement behaviour…Progression of Syndrome Specific Metabolic Brain Patterns in Patients with Various Parkinsonian Syndromes
Objective: To analyse the follow-up changes in the expression of the three syndrome specific metabolic patterns in a cohort of parkinsonian patients who underwent 18F-FDG…The correlations of RBD severity with motor and nonmotor features in isolated RBD patients
Objective: To investigate the motor and nonmotor features in isolated rapid eye movement sleep behavior disorder (iRBD) and to find the variables of polysomnography (PSG)…Visualising tau in patients with progressive supranuclear palsy using PI2620-PET
Objective: This study investigates the use of a new tau-specific PET radiotracer, [18F]-PI-2620, as a tool for visualising tau in the living brain. Background: The…Metabolic patterns and neurodegeneration in isolated REM sleep behavior disorder
Objective: To elucidate the role of Parkinson’s disease (PD)-related brain metabolic patterns as a biomarker in isolated rapid-eye-movement sleep behavior disorder (iRBD) for clinical correlation…Longitudinal 18F-PBR06 (TSPO) and Volumetric MR Imaging as Pharmacodynamic Endpoints for MSA – Ongoing Investigator Sponsored Trial of Verdiperstat
Objective: In multiple system atrophy (MSA) patients to: 1) evaluate 18F-PBR06 positron emission tomography (PET) for longitudinal assessment of 18-kilodalton-translocator protein (TSPO) binding; 2) assess…Persistent and efficient transduction of the putamen following gene therapy for aromatic L-amino acid decarboxylase deficiency
Objective: This study aimed to evaluate longitudinal transduction in subcortical regions and transduction of the cortico-putaminal network after putaminal AADC gene therapy. Background: Aromatic L-amino…Language impairment in Corticobasal Syndrome: from clinical phenotype to biomarkers
Objective: To investigate the language impairment profile of patients diagnosed as probable Corticobasal Syndrome (CBS) [1] in light of a multimodal imaging biomarkers analysis, namely…Impulse control disorder and ventral striatum dopamine D3 receptor availability in Parkinson’s disease
Objective: To investigate the relationship between ventral striatum D3 dopamine receptor availability and severity of impulse control disorder (ICD) in Parkinson’s disease (PD). Background: Reduced…
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