Clinical correlates of Parkinson’s disease metabolic pattern: not only a diagnostic tool
Objective: To define and cross-validate the glucose metabolism abnormalities related to Parkinson's Disease (PD), and to analyze pattern relationship with clinical phenotype Background: In PD,…Characteristics of the amyloid beta networks in Parkinson’s disease patients: a PPMI study
Objective: The impact that amyloid beta (Aβ) accumulation in the brain has on the progression of Parkinson’s disease (PD) pathology is complex and poorly understood…Dissociated longitudinal evolution of limbic serotonergic and striatal dopaminergic and serotonergic pathology in apathetic and non-apathetic patients in early Parkinson’s disease
Objective: To investigate the longitudinal changes in striatal and extra-striatal dopaminergic and serotonergic innervation in apathetic and non-apathetic patients during the five years after the…Cognition-related functional topographies in Parkinson’s disease: Localized loss of the ventral default mode network
Objective: We sought to determine whether functional network abnormalities seen in patients with Parkinson’s disease (PD) and cognitive decline reflect the loss of the default…Significant hypometabolism in the posterior parietal cortex and precuneus in Parkinson’s disease with GBA mutations: [18F]FDG PET study
Objective: We explored [18F]FDG PET findings of PD patients with GBA mutation. Background: Parkinson’s disease (PD) with glucocerebrosidase (GBA) mutations is characterized by early onset…Brain cholinergic dysfunction in patients with isolated REM sleep behavior disorder: A clinical and 11C-Donepezil PET follow-up study
Objective: In this follow-up study, we aimed to explore the temporal changes in brain acetylcholinesterase activity and cognitive function of iRBD patients. Background: Isolated REM…Subacute cognitive decline after DBS in a patient with idiopathic delayed-onset edema
Objective: To describe a patient who developed idiopathic delayed-onset edema (IDE) and cognitive decline three days after deep brain stimulation of subthalamic nucleus (STN-DBS). Background: IDE…Identifying the functional brain network of motor reserve in early Parkinson’s disease
Objective: To explore the functional brain network associated with motor reserve in early-stage Parkinson’s disease (PD). Background: The severity of motor symptoms in PD does…Microglial activation associated with a faster progression of nigrostriatal dysfunction in patients with isolated REM sleep behavior disorder
Objective: To assess the role of early microglial activation on the progression of nigrostriatal dysfunction, measured with 18F-DOPA PET, in isolated REM sleep behavior disorder…Increased availability of the metabotropic glutamate receptor 5 in the motor system of patients with Parkinson’s disease
Objective: To investigate glutamatergic signaling in Parkinson’s disease (PD) compared to age- and gender-matched healthy controls by using 11C-ABP688-PET combined with MRI. Background: Increasing evidence…
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