A Phase 2 Randomized Controlled Trial Repurposing Ambroxol as a Disease Modifying Treatment for Parkinson’s Disease Dementia.
Objective: Currently there are no disease-treatments for Synucleinopathies including Parkinson’s disease dementia (PDD). Our objective is to use Ambroxol to target GBA/Glucocerebrosidase to treat PDD.…Indirect Comparison of Apomorphine Sublingual Film Versus Levodopa Inhalation Powder for “OFF” Episodes in Parkinson’s Disease
Objective: Conduct a matching-adjusted indirect comparison (MAIC) of the efficacy of apomorphine sublingual film (APL) vs levodopa inhalation powder (CVT-301) for “OFF” episodes in Parkinson’s…SB-0107, a drug repurposing opportunity identified through machine learning, shows the potential to treat Parkinson’s disease motor disability and levodopa-induced dyskinesia in rat and primate models
Objective: To characterize the effects of a computationally identified small molecule in rat and primate models of Parkinson’s disease-associated motor deficits and treatment-associated complications. Background:…Safety, tolerability and CNS effects after single and multiple doses of β-agonists in healthy volunteers and patients with Parkinson’s disease
Objective: This study aimed to assess the effects of β-agonists on central nervous system (CNS) functioning in healthy volunteers and patients with Parkinson’s disease. Background:…Is past use of statins associated with lower incidence of Parkinson’s disease?
Objective: To examine the relation of past exposure to statins with Parkinson’s disease (PD) incidence. Background: Drug repurposing has recently emerged as a promising approach…Levodopa-Carbidopa Intestinal Gel Therapy for Advanced Parkinson’s Disease: A Single Center ‘Real World’ Study of Patients with and without DBS
Objective: To examine the efficacy and safety of LCIG in a ‘real world’ tertiary care center setting in patients with and without DBS. Background: Levodopa-Carbidopa…Role of Selective Serotonin Reuptake Inhibitors in the Management of Motor Tics in Tourette’s Syndrome
Objective: Determine the usefulness of paroxetine in terms of motor and behavioral manifestations control in a patient with Tourrete Syndrome (TS) with intolerance to dopamine…Adherence to medication among Serbian Parkinson’s disease patients: a cross-sectional study
Objective: This study aimed to explore patients’ adherence to antiparkinsonian medication, and to determine factors associated with low adherence among Serbian PD patients. Background: Adherence…TREMOR-LYTIC AND PREFRONTO-CORTICAL PROPERTIES OF Nigella sativa OIL IN PHENOL-INDUCED MICE MODELS OF ESSENTIAL TREMOR
Objective: This work assessed the tremor-lytic and prefronto-cortical properties of Nigella sativa oil in phenol-induced mice models of essential tremor. Background: Essential tremor is a…Evaluation of a double-target therapeutic in preclinical models of Parkinson’s disease
Objective: To evaluate the effectiveness of a candidate compound identified in a high-throughput screening (HTS) assay carried out in a Drosophila model of Parkinson’s disease…
- « Previous Page
- 1
- …
- 10
- 11
- 12
- 13
- 14
- …
- 32
- Next Page »