Levodopa-Entacapone-Carbidopa Intestinal Gel in the treatment of advanced Parkinson’s disease: a two-year experience
Objective: To evaluate the efficacy of Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIG) in the treatment of patients with advanced Parkinson’s Disease (APD). Background: The continuous enteral infusion…Rora deficiency aggravates dopamine neurons loss via reducing NAD+ level in Parkinson’s disease
Objective: To investigate the mechanism by which retinoic acid-related orphan receptor alpha(RORα) regulates NAD+ levels to dopamine neuronal degeneration in Parkinson’s Disease (PD). Background: PD is an age-related degenerative…Exercise Mitigates DNA Methylation Changes at cg17274742 Associated with the Circadian Gene Variant PER2 rs2304672: A Biobank Analysis
Objective: This research aims to dissect the influence of physical activity and circadian rhythms on neuroinflammation and neurodegenerative disease progression, focusing on Parkinson's Disease (PD).…Distinct Gut Microbiome in Parkinson’s disease Based on the Presence of Premotor Rapid-Eye Movement Sleep Behavior Disorders: Exploring the Alpha-synuclein
Objective: We aim to investigate the microbiome composition and functional profiles in Parkinson’s disease (PD) patients with and without premotor rapid eye movement sleep behavior…Increased Brain Free Water is Associated with Regional Gene Expression in Parkinson’s Disease
Objective: In this study, we used brain free water scores and regional gene expression profiles from the Allen Human Brain Atlas transcriptomic data to investigate…Abnormal basal ganglia-related functional gradient in Parkinson’s disease
Objective: The aim of this research was to investigate the basal ganglia (BG)-related functional gradient alterations and the association between these brain dysfunctions and clinical…Parkinson’s Disease-Related Pattern in isolated REM Sleep Behavior Disorder as a prodromal progression marker
Objective: To investigate expression of the PD-related pattern in 18F-FDG PET scans of iRBD patients longitudinally. Background: The Parkinson’s disease-related pattern (PDRP) might serve as…Serotonergic dysfunction and impulse control disorders in Parkinson’s disease: a double-tracer PET study
Objective: To investigate the dysfunction of the serotonergic system related to impulse control disorders in patients with Parkinson’s disease. Background: Impulse control disorders (ICDs, including…Alterations in neural processes of cognitive control in asymptomatic heterozygous mutation carriers in the Parkin gene
Objective: Investigating heterozygous Parkin gene (PRKN) mutation carriers to evaluate the potential association of this mutation with an alteration of cognitive control processes. Background: Recessively…Dopamine Dysregulation Syndrome Outcomes following Pallidal Deep Brain Stimulation in Parkinson’s Disease
Objective: To examine the impact of pallidal deep brain stimulation (DBS) on symptoms of Dopamine Dysregulation Syndrome (DDS) in Parkinson’s disease (PD). Background: DDS is…
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