Parkinson’s Disease Health Policy in 7 African Countries: Results of a Transforming Parkinson’s Care in Africa (TraPCAf) Review
Objective: To determine the inclusion of Parkinson’s Disease (PD) in African health policy, and treatment recommendations in available national policy documents. Background: Neurological disorders are…Screening for Neuronal Synuclein Disease (NSD) using cerebrospinal fluid (CSF) in the Parkinson Progression Marker Initiative (PPMI)
Objective: To utilize a centralized screening paradigm for early stage NSD based on sequential olfactory dysfunction (measured by University of Pennsylvania Smell Identification test (UPSIT))…A Phase I Study of TR-012001, a Nasal Levodopa, in Healthy Adult Japanese Male Subjects
Objective: To investigate the safety, tolerability, and pharmacokinetics of TR-012001, a nasal levodopa (LD), in healthy Japanese adult men with and without premedication with dopa…Adaptive deep brain stimulation for tremor control in Parkinson’s disease
Objective: To evaluate clinical improvements in tremor following the implementation of adaptive deep brain stimulation (aDBS). Background: Alpha-beta (8-30Hz) based aDBS is a safe and…Randomized Trial comparing Directional DBS with Ring-mode DBS in PD
Objective: To evaluate whether directional DBS is more effective in reducing PD motor symptoms and causes fewer stimulation-induced adverse effects (AE) than ring-mode DBS. Background:…Improvements in Motor and Non-Motor Symptoms of Parkinson’s Disease in Those Treated with Photobiomodulation Plus Exercise: A Sham-Controlled Study
Objective: To assess efficacy of photobiomodulation + exercise to improve Parkinson’s disease (PD) symptoms. The primary outcome measure was timed up-and-go (TUG) and other motor…Correlations of catecholamine metabolites and alpha-synuclein by nigral stimulation in Parkinson’s disease model rat
Objective: We aimed to clarify the effects of substantia nigra (SN) stimulation on catecholamine levels and α-synuclein in PD model rats. Background: Catecholaminergic neurons are…Comparative Analysis of miR-29a Expression in Optimized Medical Therapy and Intestinal Infusion Therapies in Advanced Parkinson’s Disease
Objective: To compare the relative expression of miR-29a in patients with advanced Parkinson's disease (PD) receiving optimized medical therapy (OMT) versus intestinal infusion therapies—levodopa/carbidopa intestinal…Antidepressants Associated with Worsening Dyskinesia in Parkinson’s Disease
Objective: This case report aims to highlight the impact of increasing venlafaxine dose on the worsening of dyskinesias and the onset of ocular dyskinesia³ and…Comparing the Impact of Levodopa versus Pramipexole on Eye-Tracking Parameters in Treatment-Naïve Parkinson’s Disease: A Longitudinal Study
Objective: To investigate the differential effects of levodopa versus pramipexole on eye-tracking parameters in treatment-naïve patients with Parkinson's disease. Background: Parkinson's disease (PD) is characterized…
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