Determining and Leveraging Local Ancestry to Assess Individual-Level Risk: from the Global Parkinson’s Genetics Program
Objective: We develop a scalable pipeline leveraging existing tools to determine local ancestry for all individuals in the Global Parkinson’s Genetics Program (GP2), aiming to…The Protective Effect of Sutherlandia frutescens in a Rotenone-Induced Rat Model of Parkinson’s Disease.
Objective: The objective of this study was to investigate the impact of rotenone, a pesticide associated with Parkinson's-like symptoms, and Sutherlandia frutescens (SF), a plant…Cervical Vestibular-Evoked Myogenic Potentials in Patients with Parkinson’s Disease
Objective: to examine the functioning of the brain stem and to gain insight into the irregularities of cervical vestibular-evoked myogenic potentials (cVEMPs) in patients with…Altered gut microbiota composition and metabolism in Parkinson’s disease
Objective: To define changes in gut microbiota composition and metabolism to enable identification of novel therapeutic targets and strategies for disease modification. Background: Multiple cohort…Reduced plasma levels of various cell signaling molecules in patients with Parkinson’s Disease
Objective: To define the profile of different cell signaling molecules in the blood of patients with Parkinson’s Disease (PD) compared to controls. Background: PD is…Dynamic video-assessment of axial postural abnormalities in parkinsonism: feasibility and pilot analysis
Objective: To evaluate changes in the degree of axial postural abnormalities (APAs) using the AutoPosturePD software during standing and walking under single/dual-task conditions. Background: We…Engage, Educate and Empower: Parkinson’s Research Advocates from the Black and African American Community
Objective: To assess engagement in research advocacy among Black and African people with Parkinson’s and their care partners. Background: Black and African American people with…The Pro-LBD Study Investigating Early Detection, Prognosis, and Biomarkers of Prodromal Lewy Body Diseases
Objective: The Pro-LBD cohort study is a prospective, long-term, clinic-biological cohort study of participants who are stratified by their risk of developing a Lewy body…Association between use of Furosemide and Risk of Parkinson’s disease
Objective: Main objective of study is to check the association between furosemide use and risk of Parkinson's disease (PD) in a Finnish nationwide nested case-control…MDS Clinical Supportive Criteria for Parkinson’s Disease are Associated with α-Synuclein Seed Amplification Assay Status
Objective: To assess the association between α-synuclein seed amplification assay (α-synuclein SAA) status with the supportive criteria of the MDS Clinical Diagnostic Criteria for Parkinson’s…
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