Complement C4 Exacerbates Inflammation and Neuronal Damage in Vivo
Objective: To investigate the specific effects of the core complement component C4 on α-synuclein aggregation and neuroinflammation during the pathogenesis of PD. Background: Synucleinopathies are…χ-DBS: An Open-Source Susceptibility Atlas Tool for Deep Brain Stimulation Target Visualization and Segmentation
Objective: This work is motivated by the need for atlas creation tools for susceptibility maps presurgically acquired for deep brain stimulation (DBS). Segmentations aid in…Differentiating Parkinsonism and related diseases by specific Parkinsonism patterns
Objective: This study aimed to identify characteristic parkinsonism patterns across PD, MSA and PSP, and evaluate their utility in early differentiation. Background: Parkinson's disease (PD), multiple…Dopamine Transporter Imaging as a Predictor of Functional Outcomes in Parkinson’s Disease
Objective: To evaluate the prognostic value of dopamine transporter (DAT) imaging in predicting future disability, as well as motor and non-motor burden, in Parkinson’s disease…Dual task elicited premotor and supplementary motor activity as sensitive markers of mild Parkinson’s disease: an fNIRS analysis
Objective: This study aimed to explore dual-task (DT)-related cortical hemodynamic response (CHR) differences across healthy older adults (HOA), mild Parkinson’s disease (PD), and moderate PD…A Multi-Transcriptional Risk Score Approach to Parkinson’s Disease Prediction
Objective: To improve the prediction of Parkinson’s disease (PD) by examining aggregate profiles of gene expression in the form of transcriptional risk scores (TRS). Background:…Disclosing CLIA certified genetic results within the LARGE-PD Cohort in Peru: Preliminary results of the PD GENEration study
Objective: To characterize the Peruvian Parkinson’s disease (PD) cohort within the Latin American Research Consortium on the GEnetics of Parkinson Disease (LARGE-PD) that received a…16-years of Evaluations for Prodromal Parkinson Features in an At-Risk Cohort with Gaucher Disease
Objective: To evaluate prodromal features of Parkinson disease in a cohort of "at-risk" Gaucher patients and GBA1 carriers . Background: Variants in GBA1 mutations are…VPS13C: a Modifier Gene causing Suboptimal Response to Levodopa in Early-Onset Parkinson’s Disease
Objective: To describe a retrospective clinical study of four cases carrying heterozygous pathogenic variants in the VPS13C gene with a clinical diagnosis of Early-Onset Parkinson’s…The Global Parkinson’s Genetics Program: Expanding the Diversity of Neurological Disorder Data: 2025 Update
Objective: To broaden the available data for Parkinson's Disease (PD) and related disorders by integrating genetic data from more than 115,000 participants worldwide through genotyping…
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