PINK1 activation improves outcomes in the UQCRC1 models of Parkinson’s disease
Objective: To investigate the role of chronic oxidative phosphorylation (OXPHOS) stress in mitophagy and the therapeutic potential of PINK1 activation in the UQCRC1 models of…Profiling Neural Protein Dopaminylation in Parkinson’s disease
Objective: The hallmark of Parkinson’s Disease is motor dysfunction from the decline in dopaminergic cells in the substantia nigra (SN), leading to the development of…Effect of Aβ on α-synuclein propagation
Objective: To investigate how amyloid-beta (Aβ) pathology affects α-synuclein (α-syn) propagation. Background: Lewy bodies, the pathological hallmark of Parkinson’s disease and dementia with Lewy bodies,…Prevalence and Clinical Characteristics of iNPH-Related Imaging Findings (DESH) in Parkinson’s Disease
Objective: To investigate the prevalence of idiopathic normal pressure hydrocephalus (iNPH)-related imaging findings (DESH) and their clinical characteristics in Parkinson’s disease (PD) patients. Background: PD…MultiModal Transformer-Based Detection of Parkinson’s Disease in fMRI Extracted Time Series
Objective: Develop and evaluate a multimodal, transformer-based pipeline for detecting Parkinson’s disease (PD) from resting-state fMRI time series, aiming to expose short-lived neural connectivity disruptions…Brain hemodynamic responses to a motor control paradigm in younger and older adults, and people with Parkinson’s Disease: An fNIRS mediated feasibility study.
Objective: This study aims to investigate the use of fNIRS in measuring the hemodynamic response of the brain during motor control tasks of increasing complexity…First in Class ASO Targeting A53T Allele: Preclinical Efficacy
Objective: Our objective was to develop an antisense oligonucleotide (ASO) allele-specific strategy to target the mutant A53T SNCA allele, reducing aberrant α-synuclein production, without downregulating…Rapid Neurologic Decline after Subthalamic Nucleus Deep Brain Stimulation in Leucine-Rich Repeat Kinase 2 Parkinson’s disease (LRRK2-PD)
Objective: To describe the clinical outcomes of two unrelated patients with LRRK2-PD who experienced rapid neurologic decline following subthalamic nucleus deep brain stimulation (STN-DBS). Background:…Genetic Analysis of Parkinson’s Disease in Crete
Objective: We aimed to investigate the genetic architecture of Parkinson’s disease (PD) in the island-based Cretan population by identifying pathogenic/likely pathogenic variants (ACMG criteria), in…Insights into Ancestral Diversity in Parkinson’s Disease Risk: A Comparative Assessment of Polygenic Risk Scores
Objective: This study aims to provide a comprehensive assessment of PRS performance across ancestries and highlight the limitations of a “one-size-fits-all” approach to genetic risk…
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