The Transcriptomic, Neurotransmitter, and Cell Type Signatures Underlying Pure Fatigue in Early-stage Parkinson’s Disease
Objective: This study elucidates spatiotemporal functional connectivity of pure fatigue in early Parkinson’s disease (PD) and uncovering underlying gene expression profiles. Background: Fatigue is a…Nutritional Status as a Modifiable Determinant of Clinical Outcomes in Parkinson’s Disease: A 12-Month Longitudinal Study in Patients Treated with DBS and L-Dopa
Objective: To analyze longitudinal changes in nutritional status in Parkinson’s disease (PD) patients treated with deep brain stimulation (DBS), compared with pharmacological therapy (L-dopa) and to…Visualization of Small Brainstem Nuclei With the Ultra-High Performance NeuroEXPLORER PET Camera: a Comparison Study Using 18F-AV133
Objective: To compare the performance of 18F-AV133 between NeuroEXPLORER (NX) and standard resolution Siemens Biography (mCT) positron emission tomography (PET) cameras in people with Parkinson's…Early Complement Activation Prunes Inhibitory Synapses in Prodromal Synucleinopathy Independent from Lewy Pathology.
Objective: To identify early molecular and cellular changes associated with dopaminergic neuron vulnerability and synuclein pathology across different disease contexts. Background: Parkinson’s disease (PD) is…Temporal Ordering of Biomarker Abnormality Events Leading to Cognitive Impairment in Parkinson’s Disease: A Disease Event-Based Model Analysis of the PPMI Cohort
Objective: To estimate the temporal ordering of multimodal biomarker abnormality events leading to cognitive impairment in PD using a Disease Event-Based Model (DEBM), incorporating clinical,…A Randomized Controlled Trial Evaluating Ankle Pump Combined with Compression Abdominal Belts on Orthostatic Hypotension in Patients with Parkinson’s Disease
Objective: To investigate the short-term efficacy of ankle pump exercise combined with automated compression abdominal belts on orthostatic hypotension (OH) and orthostatic intolerance symptoms in…Beta and Gamma Local Field Potentials in Chronic Deep Brain Stimulation for Parkinson’s Disease: Programming Implications from a Systematic Review
Objective: To define distinct clinical roles of beta- and gamma-band local field potential (LFP) biomarkers in chronic deep brain stimulation (DBS) for Parkinson’s disease (PD)…Prediction of Cognitive Decline After STN-DBS in Parkinson’s Disease Using Preoperative Electroencephalography and a Deep Learning Model
Objective: To determine whether preoperative electroencephalography (EEG) combined with deep learning can predict cognitive decline 1 year after subthalamic deep brain stimulation (STN-DBS) in patients…Disassembly of α-Synuclein Aggregates by the All-D-peptide PRI-101: Preclinical Efficacy in Vitro and in Vivo.
Objective: To develop a disease-modifying therapy for Parkinson’s disease (PD) and related synucleinopathies by eliminating intracellular, toxic, and seeding-competent aggregate species of α-synuclein (α-syn). Background:…To Protect Life and Safeguard Autonomy: Ambiguous Expressions of the Will to Live
Objective: This study examines the ethical and legal criteria for determining a patient’s authentic will in late-stage Parkinson’s disease when refusal of life-sustaining measures occurs…
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