Deep Brain Stimulation of the Subthalamic Nuclei in Advanced Parkinson’s Disease what Effects on Motor Non-motor and Neuropsychological Functions a Monocentric Prospective Study with a 12-month Follow-up
Objective: The aim of the study is to assess the evolution of motor symptoms (MS), non-motor symptoms (NMS) and neuropsychological functions (NF) in Parkinson's disease…Repurposing Anti-Gout Medications for the Treatment of Parkinson’s Disease
Objective: To undertake a repurposing drug screen for Parkinson’s disease (PD) and further investigate the mechanism of action of top hits. To assess, in vivo,…Simulated Space Gravity Recapitulates Parkinson’s Disease Pathology in Neural Cell Model
Objective: This investigation centers on the potential influence of microgravity on α-synuclein aggregation, a hallmark feature of Parkinson's disease (PD) characterized by the formation of…Untargeted Serum Metabolomics Identifies Glycine-Serine Metabolism Disruption as Biochemical Bignature in Parkinson’s Disease
Objective: We attempted to identify a metabolomic signature distinctive of Parkinson’s disease (PD) through an untargeted metabolomics approach. Background: Using an high-performance liquid chromatography targeted…The Impact of Drug Interactions on the results of DAT-SPECT Imaging in a Specialty Movement Disorders Practice: A Retrospective Analysis of Outcomes
Objective: This study was a retrospective chart review of patients who underwent DAT-SPECT imaging for parkinsonism while on drugs listed as potentially interacting with the…Longitudinal change in brain function and structure related to plasma neurofilament light protein in early-stage Parkinson’s disease
Objective: We aimed to explore the relationship between the pNfL and change in the brain in early-stage PD using a longitudinal brain imaging cohort. Background:…Impact of Altered Cerebrovascular Reactivity on Midbrain Degeneration, Perfusion and White Matter
Objective: To evaluate whether altered cerebrovascular reactivity contributes to midbrain degeneration, perfusion abnormalities, or white matter disease in patients with Parkinson’s disease (PD). Background: Cerebrovascular…Dopaminergic denervation and focal motor progression in early Parkinson’s Disease: A 5-year longitudinal study
Objective: To evaluate the progression of posterior putamen dopaminergic denervation in relation to motor progression in the less affected and more affected side of the…Sex Cerebral Vasoreactivity Differences in Parkinson’s Disease: Uncovering the Tip of the Iceberg
Objective: To determine sex differences in cerebral vasoreactivity (cVR) in patients with Parkinson’s disease (PD) and its association with the clinical spectrum of the disease.…Is GPI DBS as effective to STN DBS for tremor control in Parkinson’s disease?
Objective: To compare the benefits of GPI and STN DBS on tremor in Parkinson’s disease (PD). Background: DBS is a highly effective surgical therapy for…
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