LRRK2 Inhibition by BIIB122 / DNL151: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Ph 1 Healthy Volunteer and Ph 1B Parkinson’s Disease Trials
Objective: To evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of the LRRK2 inhibitor, DNL151 (BIIB122), in healthy volunteers (HVs) and Parkinson’s disease (PD) patients. Background:…Towards an automated rating of the MDS-UPDRS motor scores.
Objective: This study aimed at developing an automated rating method for the MDS-UPDRS motor scores in Parkinson’s disease (PD) patients. This automated rating uses inertial…Prasinezumab reduced progression of Parkinson’s disease motor features measured by Roche PD Mobile Application v2 sensor features: PASADENA Phase II Part 1
Objective: To determine whether digital biomarker sensor data detect slowing in progression of core motor features of Parkinson’s disease (PD) in individuals with early PD…Determination of the motor status after the implementation Levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease using a Machine learning Algorithm
Objective: Aim of this study was to develop a random forest (RF)-based PD model to determine the postoperative motor outcome at 2 years follow-up after…Opicapone in Clinical Practice in Parkinson’s Disease UK Patients with Motor Fluctuations: Findings from the OPTIPARK Study
Objective: To evaluate opicapone (OPC) when used in everyday clinical practice conditions to treat Parkinson’s disease (PD) patients with motor fluctuations. Background: OPC proved to…STATINS IN PARKINSON’S DISEASE: INFLUENCE ON MOTOR PROGRESSION
Objective: To evaluate whether long-term statin use may affect motor progression in a large cohort of de novo patients with Parkinson's Disease. Background: Statins are…Wearable sensor motor outcomes across patients with Parkinson’s disease from Asian, Black, and Caucasian ethnicity in the United Kingdom
Objective: To determine the effect of ethnic background on motor scores in people with Parkinson’s disease (PwP) using objective measurement. Background: Limited evidence has suggested…Clinical Outcomes in Parkinson’s with COVID 19 during the’ first wave’ in West Berkshire, United Kingdom (UK)
Objective: To review the outcomes of COVID 19 during the first wave in patients with Parkinson’s in West Berkshire, UK. Background: UK is one of…Long-term cognitive and motor decline across the spectrum of Lewy body disease.
Objective: This study aims to compare the progression of motor and cognitive decline in dementia with Lewy bodies (DLB) compared with Parkinson’s disease (PD) using…Cognitive assessment of Parkinson’s Disease patients in a Northeast Brazilian population: Current Challenges
Objective: To evaluate the influence of education level in the Mini-Mental Status Examination (MMSE) score in Parkinson’s Disease (PD) patients in a northeast Brazilian sample.…
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