Lymphocyte count/neutrophil-to-lymphocyte ratio and mild cognitive impairment in Parkinson’s disease
Objective: The present study aimed to elucidate whether i) lymphocyte count and neutrophil-to-lymphocyte ratio (NLR) can discriminate Parkinson's disease (PD) patients from healthy controls (HC);…Developing zebrafish CRISPR/Cas9 knockout models of Parkinson’s Disease to identify novel therapeutic targets.
Objective: Human patients present punctual mutations and/or small deletions in genes that have been associated with Parkinson’s disease, namely, park1, park2, park6, park7, and park8.…No evidence for the impact of SNCA rs356219 on Parkinson’s disease progression
Objective: To replicate findings from previous studies reporting an association between the α-synuclein (SNCA) rs356219 genetic variant and progression to key outcomes in Parkinson’s disease…Real-World Deep Brain Stimulation Outcomes Using DBS Systems with Directionality and Multiple Independent Current Control
Objective: We report clinical outcomes associated with the use of Deep Brain Stimulation (DBS) systems capable of directionality and Multiple Independent Current Control (MICC). Background:…Imaging progressive peripheral and central dysfunction in isolated REM sleep behaviour disorder after 3 years of follow-up
Objective: To image progression of intestinal dysfunction, cardiac sympathetic denervation, and dopaminergic nigrostriatal damage in patients with isolated REM sleep behaviour disorder (iRBD). Background: A…Measuring what matters in Parkinson’s disease – validating real-world digital mobility outcomes for widespread adoption
Objective: To validate and support widespread adoption of real-world digital mobility outcomes (DMOs) to monitor mobility performance, disease progression and predict falls in patients with…Relation of affective disorders and quality of life in the chronic pain of disease Parkinson’s patients
Objective: To study affective disorders and their impact on the quality of life in patients with PD and chronic pain syndrome. Background: Mechanisms of the…Inducing motor cortical plasticity in Parkinson’s Disease patients using subthalamic deep brain stimulation and repetitive transcranial magnetic stimulation
Objective: To investigate whether motor cortical plasticity can be induced in Parkinson’s disease (PD) patients by pairing subthalamic deep brain stimulation (STN-DBS) and repetitive transcranial…Clinical phenotype of non-manifesting carriers of mutations in the GBA and LRRK2 genes
Objective: To explore the influence of carrying mutations in both the GBA and LRRK2 genes (dual mutation carriers) on risk for future development of Parkinson's…Outcomes after Deep Brain Stimulation (DBS) surgery in patients with young-onset Parkinson’s disease
Objective: To assess outcomes after deep brain stimulation (DBS) in patient with young-onset Parkinson’s disease (PD). Background: DBS is a surgical procedure which effectively treats…
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