A progress update on the Critical Path for Parkinson’s consortium’s pre-competitive 3DT initiative
Objective: To provide a progress update on the Critical Path for Parkinson’s (CPP) consortium’s “Digital Drug Development” (3DT) initiative, which was established in 2019 with…The acceptability of wearable devices to measure mobility in people with Parkinson’s Disease: observations from Mobilise-D
Objective: To explore the acceptability of wearable devices to remotely measure mobility in the Mobilise-D technical validation study (TVS). Background: When deploying tools to monitor…Classification of extremity movements by visual observation of signal transforms
Objective: To create a tool for raters certified in the MDS-UPDRS) [1] to blindly score online signal transforms of the output of the wearable sensors to…Clinical Characteristics of patients with Parkinson’s disease showing normal values on SBR in the DAT SPECT
Objective: The aim of this study was to clarify what the ‘normal’ values of the specific binding ratio (SBR), a measure of striatal radiotracer uptake…iFall: Usability of a co-produced falls reporting smartphone application in people with Parkinson’s
Objective: To assess the usability of a co-produced smartphone application for falls reporting in people with Parkinson’s (PwP) Background: Falls commonly occur in PwP, which…Long-Term Neuropsychological Outcomes of Deep Brain Stimulation in Early-Stage Parkinson’s Disease
Objective: To report long-term (5-year and 11-year) neuropsychological outcomes from the deep brain stimulation (DBS) in early-stage Parkinson’s disease (PD) pilot clinical trial. Background: The…Challenges and Opportunities People with Parkinson’s Disease Experienced Pre and Post-Covid-19 Vaccination
Objective: To determine the specific challenges and opportunities people with Parkinson’s disease (PWP) experienced before and after receiving the Covid-19 vaccine. Background: The Covid-19 pandemic…Utility of Seed Amplification Assay for Detecting α-synuclein in Formalin-Fixed Paraffin Embedded Skin Samples in Parkinson’s Disease
Objective: To determine the sensitivity for Parkinson’s disease (PD) diagnosis of seed amplification assay (SAA) for α-synuclein (α-syn) in formalin-fixed paraffin-embedded (FFPE) skin specimens and…Inflammatory biomarkers in newly diagnosed patients with Parkinson’s disease
Objective: To identify a panel of cerebrospinal fluid (CSF) inflammatory biomarkers for Parkinson’s disease (PD) and to compare levels of inflammatory proteins in control subjects…Investigation of Modifiers of β-Glucocerebrosidase in Cell Models of Parkinson’s Disease
Objective: We firstly aim to identify modifiers of β-glucocerebrosidase (GCase) activity and expression in Parkinson’s disease (PD) relevant cell models. We secondly aim to ascertain…
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