Circadian cycle and disease phenotype in Parkinson’s disease, insights by motion sensors and molecular biology.
Objective: Our aim is to investigate whether the circadian cycle (CC) is linked to the patient Parkinson's disease (PD) profile on a clinical and molecular…Telemedicine in speech and swallowing disorders for patients with Parkinson’s disease: Motivation and satisfaction of patients and speech language pathologists
Objective: To assess the satisfaction with telemedicine for speech and swallowing disorders among patients with PD and speech language pathologists (SLP) as well as the…Importance of lifestyle advice for participants in studies of early Parkinson’s disease
Objective: Estimating the ethical acceptability of early Parkinson’s Disease (PD) research among healthy individuals participating in a PD screening study in terms of risk disclosure…Second Project: The feasibility and efficacy of virtual visits compared to in-person visits for management of Parkinson’s disease. A pilot, international, longitudinal, multicenter trial (NCT04695353).
Objective: To investigate the feasibility and efficacy of virtual visits for Parkinson's Disease (PD) compared to in-person visits. Background: Considering the limited access to specialists…Oscillatory activity of pause-burst STN neurons shows an association with motor symptoms of Parkinson’s disease
Objective: Here we aimed to investigate heterogeneity in the neuronal activity within the subthalamic nucleus (STN) to search the association between oscillatory activity and motor…Assessment of microstructural changes associated with levodopa-induced dyskinesia in hemiparkinsonian rodents
Objective: To assess white matter (WM) microstructural integrity changes in pre-clinical models of Parkinson’s disease (PD) with levodopa-induced dyskinesia (LID). Background: PD is a neurodegenerative…Investigating the use of DAT-SPECT as an enrichment biomarker to determine eligibility for the phase 2 clinical trial PASADENA
Objective: Evaluate dopaminergic imaging DAT-SPECT as an enrichment strategy to avoid inclusion of participants with scans without evidence of dopaminergic deficit (SWEDD) in a Phase…Long-term follow-up of subthalamic nucleus deep brain stimulation for Parkinson’s disease: survival and disability milestones
Objective: To characterize retrospectively the long-term survival of 109 PD patients after 8 years of STN-DBS and to identify the incidence of the milestones of…Cortical beta activity in doorway-provoked motor blocks in Parkinson’s disease
Objective: To investigate cortical activity of doorway-provoked motor blocks (MB) during pedalling in Parkinson’s disease (PD). Background: Freezing of gait (FOG) is common in PD…Motor-Related and Cognition-Related Safety of Pimavanserin in Patients with Parkinson’s Disease Psychosis (PDP)
Objective: Evaluate motor- and cognition-related safety in pimavanserin-treated patients with PDP. Background: Pimavanserin, a selective 5-HT2A inverse agonist/antagonist, is the only US FDA-approved treatment for…
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