Nicotine and influences on hyperkinetic movement disorders
Objective: We describe hyperkinetic movement disorders with a variable response to smoking and nicotine and review clinical and pre-clinical evidence regarding the role of smoking,…Long-term outcome of adaptive DBS using LFP sensing technology
Objective: The aim of this study was to clarify the long-term outcome of Parkinson’s disease patients receiving STN-DBS with adaptive DBS setting. Background: It has…The anti-alpha-synuclein antibody Lu AF82422 was safe and well tolerated in a FIH-SAD study in healthy subjects and patients with PD
Objective: Evaluation of safety, tolerability, pharmacokinetics (PK) and target engagement (TE) in healthy subjects (HS) and patients with Parkinson’s disease (PD) following single ascending doses…The anti-alpha-synuclein antibody Lu AF82422 binds to pathological alpha-synuclein species from human brains and inhibits seeded alpha-synuclein aggregation
Objective: Lu AF82422 is a human IgG1 monoclonal antibody that binds all known forms of alpha-synuclein (aSyn), including monomeric, aggregated and truncated. Data are presented…Evaluation of the association between total electrical energy delivered (TEED) and cognitive function six months after DBS in patients with Parkinson’s disease
Objective: We aimed to investigate the neuropsychological outcome six months after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkison's disease (PD) patients and…Mapping Side Effects in Deep Brain Stimulation – Different Approaches, Different Problems.
Objective: This study aims to evaluate different strategies to map DBS‑induced side‑effects regarding their ability to create anatomically plausible stimulation maps and to predict side‑effect…Meta-optimization to select stimulation settings for deep brain stimulation in Parkinson’s disease
Objective: The objective is to develop an algorithmic approach for selecting deep brain stimulation (DBS) settings for Parkinson’s disease (PD) and other movement disorders more…The cortical thickness signature and future phenoconversion in isolated REM-sleep behavior disorder: a longitudinal analysis
Objective: To develop an imaging biomarker predicting subtype-specific phenoconversion in isolated REM sleep behavior disorder (iRBD), we aim at identifying MRI-driven cortical thickness signature in…Directional DBS – Early experiences with “Current steering” in India
Objective: Deep Brain Stimulation using directional leads is relatively recent in India. We present our early experiences with the same. Background: Deep brain stimulation (DBS)…Increased alpha-synuclein level in primary macrophages derived from patients with Parkinson’s disease
Objective: To assess glucocerebrosidase and alpha-synuclein level in primary macrophages derived from patients with Parkinson’s disease with and without GBA1 mutation. Background: Parkinson’s disease (PD)…
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