The Effect of Melatonin on Sleep Quality and Daytime Sleepiness in Parkinson’s Disease: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials
Objective: This study aims to systematically quantify the impact of melatonin on sleep quality and daytime sleepiness in individuals diagnosed with Parkinson’s disease (PD). Background:…Subdomain-specific cognitive decline and its effect on caregiver burden in Mexican population living with Parkinson’s Disease.
Objective: To determine whether different subdomains of the MoCA associate with caregiver burden. Background: Caregivers improve the quality of life for Parkinson's patients (PwP), despite…Qualitative research in advanced Parkinson’s disease: Exploring salient symptoms and suitability of the MDS-NMS from the patient, caregiver, and clinician perspective
Objective: To identify which non-motor symptoms (NMS) are most relevant in an advanced Parkinson’s Disease (PD) population and determine the suitability of the International Parkinson…Assessing Physiotherapy’s Role in Parkinson’s Disease Functionality in India: A Case Report
Objective: To find out the Assessing Physiotherapy's Role in Parkinson’s Disease Functionality in India: A Case Report Background: This case report explores the impact of…Wearable-based digital measures from the Verily Study Watch can detect concurrent symptomatic treatment effects in a subset of early-stage Parkinson’s disease ORCHESTRA trial participants
Objective: To investigate the effect of concurrent symptomatic treatment (ST) on digital measures collected in ORCHESTRA (NCT04658186). Background: Minzasolmin is an oral small molecule that…Proof-of-Concept Study Design Leveraging Digital Biomarkers to Enhance Statistical Power and Reduce Sample Size in PD Trials
Objective: Parkinson's disease clinical studies for disease modifying therapies face challenges of large sample size and long study duration due to subtle changes at early…A randomised controlled feasibility study of a technology-assisted home-based aerobic exercise program for individuals with Parkinson’s disease
Objective: The study evaluates the effectiveness of Combat PD, a mobile app designed to remotely deliver and monitor gamified aerobic exercise in promoting adherence and…A Phase II Randomized, Parallel, Double-blind, Placebo-controlled Study of the Efficacy and Safety of WD-1603 in Subjects with Parkinson’s Disease
Objective: To investigate the effectiveness, safety and pharmacokinetics of WD-1603 carbidopa-levodopa controlled-release tablets in subjects with Parkinson's disease. Background: The development of drug products that…A Systematic Site Selection Approach to Ensure Efficient and Diverse Participant Recruitment to a Large-Scale Multi-Arm, Multi-Stage Platform Trial for Parkinson’s
Objective: To select up to 40 delivery sites to successfully recruit and retain a participant population representative of people with Parkinson’s disease (PwP) in the…Peripheral insulin resistance may predict exenatide treatment response in Parkinson’s disease
Objective: To explore if the glucagon-like peptide-1 (GLP-1) receptor agonist, exenatide could modify the course of Parkinson’s disease (PD) and if peripheral insulin resistance (IR) mightdifferentially impact on this. Background: Exenatide…
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