Improving the design of clinical trials in early-stage Parkinson’s disease by using the estimand framework
Objective: To show how the estimand framework can be used to improve design of clinical trials testing treatments in early-stage Parkinson’s disease (PD). Background: The…Validation of a wireless Home-Based Sleep Laboratory for assessment of sleep-related disorders in Parkinson’s disease
Objective: To examine the validity of a new wireless wearable system which measures EEG, EOG and sEMG for the assessment of sleep and sleep related…The effect of rasagiline on nocturnal hypokinesia: the analysis of the Nocturnal Hypokinesia Questionnaire (NHQ)
Objective: To identify the effect of rasagiline on nocturnal hypokinesia based on Nocturnal Hypokinesia Questionnaire (NHQ). Background: Nocturnal hypokinesia refers to the difficulty or the…The role of cortical and subcortical structures in maintaining efficient network topology in Parkinson’s disease
Objective: To assess the relative importance of cortical and subcortical nodes and their connections in maintaining efficient structural connectome topology in Parkinson's disease (PD). Background:…Dried blood and plasma spots for the measurement of neurofilament light chain and inflammatory cytokines in patients with REM sleep behaviour disorder
Objective: The objective of this study was to investigate the relationship between plasma and dried blood/ plasma spot measurements of inflammatory markers (IFN-ɣ, IL-1β, IL-6,…Single-cell characterization of patient midbrain tissue reveals tissue remodeling and glial activation in Parkinson’s disease
Objective: We aim to characterize the contribution of each midbrain cell type to PD pathology, and to identify cell types associated with genetic PD-risk variants.…Quality of life changes after subthalamic stimulation for Parkinson’s disease depend on nonmotor and motor symptoms clusters
Objective: To analyze quality of life (QoL) changes after subthalamic stimulation (STN-DBS) based on a short list of baseline nonmotor and motor symptoms in Parkinson’s…Neural activity during turning in Parkinson’s: influence of dual-task and freezing
Objective: To examine the neural activity during turning in Parkinson’s disease (PD). Background: Turning is impaired in PD with links to freezing of gait (FOG)…A Potential Cluster Near Site of Dry Cleaning Contamination
Objective: To characterize specific health outcomes of people with potential exposure to chemicals used in dry cleaning. Background: Trichloroethylene (TCE) is a chlorinated solvent used…Value of Archimedes spiral in tremor.
Objective: Retrospective study whose main objectives is to describe the characteristics of Archimedes spiral (AS) (presence of axis and direction) and to relate them to…
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