Non-apoptotic caspase-3 activation mediates early synaptic dysfunction of indirect pathway neurons in the parkinsonian striatum
Objective: We set out to investigate whether caspase-3 plays a role in the loss of dendritic spines and the concomitant synaptic deficits that develop in…Multimodal assessment of nigrostriatal degeneration in de novo Parkinson’s disease
Objective: To study nigrostriatal changes with a multifactorial neuroimaging approach in order to further characterize early abnormalities in Parkinson’s Disease (PD). Background: Imaging techniques allow…Quality of Life in African American and White Parkinson’s Disease Patients
Objective: To determine the quality of life of African American (AA) and White patients with Parkinson’s disease (PD) at the Rush University Medical Center (RUMC)…Nutritional Status in Advanced Parkinson’s Disease: Preliminary Results.
Objective: To analyze the relationship between nutritional intake and weight aspects in 3 groups of patients with Parkinson's disease (PD) who are receiving different pharmacological…Exploratory analysis of the effect of delayed-start prasinezumab on motor sign progression measured with the Roche PD Mobile Application v2: PASADENA Phase II Parts 1 and 2
Objective: To determine whether the positive effects of prasinezumab on motor progression measured by Roche PD Mobile Application (PASADENA study Part 1; 0-52 weeks; NCT03100149)…Effect of CDNF in a novel combination stressor model of Parkinson’s disease
Objective: In this study, our first aim was to develop a model for Parkinson's disease (PD) that would exhibit the alpha-synuclein (αSyn) aggregation pathology and…A fully immersive virtual reality environment to study gait modulation in Parkinson’s disease
Objective: To investigate the safety and efficacy of a fully immersive virtual reality (VR) paradigm to study gait modulation in subjects with Parkinson’s disease (PD).…NODDI- based maps as potential marker for Parkinson’s Disease.
Objective: To assess the predictive power of Diffusion Kurtosis Imaging (DKI) parameters obtained from Neurite orientation dispersion and density imaging tool (NODDI) to differentiate between…Are Subjective Cognitive Complaints a predictor of future cognitive decline in Parkinson´s Disease? – A longitudinal study
Objective: We aim to determine whether subjective cognitive complaints (SCC) may predict the development of cognitive impairment in Parkinson´s Disease (PD) Background: Subjective cognitive complaints…Repetitive transcranial magnetic stimulation for hypokinetic dysarthria in PD enhances white matter integrity in the auditory-motor loop tract
Objective: To test effects of repetitive transcranial magnetic stimulation (rTMS) for hypokinetic dysarthria in PD on white matter integrity changes of the left anterior arcuate…
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