Exploring the Therapeutic Target for Lewy Body Disease using gba1 Knock-out Medaka
Objective: This study was performed to explore the therapeutic target for Lewy body disease. Background: Lewy body disease (LBD), including Parkinson's disease and diffuse Lewy…Sphingomyelinase Activity in Patients with Sporadic Parkinson’s Disease
Objective: To measure the sphingomyelinase (ASMase) activity in sporadic PD patients and matched healthy controls and identify any clinical or biological correlation with disease’s severity.To…Machine Learning Model Comparison for Freezing of Gait Prediction in Advanced Parkinson’s Disease Patients
Objective: This study compares the performance of machine learning classification models in predicting freezing of gait (FoG) from instrumented stand-and-walk trials in advanced Parkinson’s disease…Use of Machine Learning for Identification of Parkinson’s Disease and Mild Cognitive Impairment through Neuroimaging and Biofluid Biomarkers: A Study from the PPMI Cohort
Objective: Since current diagnostic tests for Parkinson’s Disease (PD) and mild cognitive impairment (MCI) focus on individual biomarkers, misdiagnoses can be frequent. This research aims…the Degeneration of Locus Coeruleus and its Enhanced Causal Relationship to Neural Circuit in Parkinson’s Tremor
Objective: We aim to decode the neuroimaging features of LC in Parkinson's tremor. Background: Tremor is the primary symptom of Parkinson's disease (PD) and exhibits…Effects of striatal dopamine depletion and altered brain metabolism on Parkinson’s disease
Objective: To investigate the relationship between striatal dopamine depletion, altered brain metabolism, motor deficits, and cognitive dysfunction in Parkinson’s disease (PD) Background: PD shows degeneration…Assessment of Visual Field in Patients with Moderate-to-Severe Parkinson’s Disease
Objective: Utilization of visual field testing and diffusion tensor imaging (DTI) to assess visual field deficits in patients with moderate-to-severe Parkinson’s Disease (PD) and identify…Predictive elements for unilateral prelemniscal radiations radiofrequency lesions: A novel surgical approach for alleviating motor symptoms in Parkinson’s disease
Objective: A cohort of individuals diagnosed with Parkinson's disease (PD) underwent treatment with unilateral prelemniscal radiation radiofrequency lesions (U-Raprl). This research seeks to assess prognostic…Cluster Analysis of Stimulation-Induced Dysarthria Subtypes in People with Parkinson’s Disease and Subthalamic Deep Brain Stimulation
Objective: To establish different clusters with distinctive speech characteristics in people with Parkinson’s disease (PwPD) who experience stimulation-induced dysarthria (SID). Background: To date, the effect…Longevity of Motor Benefit Achieved with Deep Brain Stimulation (DBS) of the Subthalamic Nucleus (STN) in a Single Center Cohort at the Decade Mark Post-Implantation.
Objective: To track the degree and longevity of motor benefit achieved with STN DBS at our center. Background: Caputo et al., (2017)[1] presented data from…
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