Sex differences in prodromal Parkinson’s disease (PD)
Objective: To explore sex-specific differences in symptoms of prodromal Parkinson's in the PREDICT-PD cohort Background: Multiple lines of evidence suggest that biological sex is an…Exploring expectation bias in Parkinson’s disease clinical trials by comparing placebo arm progression on MDS-UPDRS to a natural history dataset
Objective: To examine baseline characteristics and disease progression of newly diagnosed Parkinson’s disease (PD) patients enrolled in clinical trials vs natural history. Background: Differences in…Impact of parkinson’s disease on work disability: a cross-sectional study
Objective: To evaluate the impact of Parkinson’s disease (PD) on work disability and identify clinical and demographic factors associated with occupational impairment. Additionally, this study…Neuroprotective Effects of ATP6V0C Overexpression in PFF Model Mice
Objective: Elucidating the role of lysosomal dysfunction due to altered stability and expression levels of V-type proton subunit ATP6V0C in the degradation and propagation of…Impaired Speech Perception in Noise (SPiN), Hearing Loss, and Cholinergic Denervation in Parkinson’s Disease
Objective: This study will investigate the relationships among speech-perception-in-noise (SPiN), hearing acuity, and cholinergic system changes in patients with PD. Background: Recent studies highlight a…Fatty Acid Metabolic Reprogramming Regulates Glial-Epithelial Axis via Nur77 Palmitoylation in Intestinal Dysfunction in Parkinson’s Disease
Objective: This study aims to elucidate the regulatory role of stearoyl-CoA desaturase 1 (SCD1) in Parkinson’s disease (PD)-associated intestinal dysfunction, focusing on its mechanism in…Transcranial sonography in Parkinson’s disease patients
Objective: To present the usage and results of transcranial sonography (TCS) in Parkinson's disease (PD) patients. Background: (TCS) has emerged as a valuable diagnostic tool…Exploring local gyrification index to understand Parkinson’s disease with mild cognitive impairment
Objective: To investigate correlations between local gyrification index (LGI) and neuropsychological variables in participants with Parkinson's disease (PD) experiencing mild cognitive impairment (PD-MCI). Background: PD…Cholinergic activity associates with cognitive function in PD using [18F]VAT
Objective: To map the relationship between cholinergic activity in Parkinson Disease (PD) and cognitive performance and identify any differences in this relationship in cognitive impairment.…Sex-Dependent Associations Between PGLYRP2 Variants and Parkinson’s Disease Across Diverse Ancestries
Objective: To investigate the association between PGLYRP2 polymorphisms and Parkinson’s disease (PD) across diverse ancestral populations. Background: Emerging evidence suggests a role of the gastrointestinal…
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