The feasibility and efficacy of speech therapy via video call in patients with Parkinson’s disease: a preliminary study
Objective: To evaluate the feasibility and efficacy of video call-based speech therapy for patients with Parkinson’s disease (PD) with speech problems. Background: PD patients commonly…The natural history of Parkinson’s disease in LRRK2 G2019S carriers
Objective: To document differences between the evolution of self-reported symptoms and prodromal markers in LRRK2 G2019S carriers and non-carriers with and without Parkinson’s Disease (PD).…Management of Sigmoid Volvulus in Parkinson’s patients presenting to Royal Berkshire Hospital, Reading ,UK.
Objective: To evaluate acute management of volvulus in Parkinson’s Background: Constipation affects upto 50% of patients with Parkinson's and sigmoid volvulus is an under recognized…Demographic, clinical and genetic factors affecting amantadine response among patients with Parkinson disease
Objective: To identify factors that correlate with efficacy and tolerability of amantadine to predict therapeutic outcomes Background: Amantadine is the only commercially available medication to…Substantia Nigra blood-brain barrier opening in Parkinson´s disease: PET (18F-Choline) evidence of parenchymal penetration
Objective: To evaluate clinical safety, feasibility, and tissue penetration (by 18F-Choline PET) of MR-guided focused ultrasound (MRgFUS) blood-brain barrier opening (BBB-O) of the substantia nigra…Identification of pre-frailty in the elderly through serum metabolomics and its impact on Parkinson’s disease phenotype
Objective: We attempted to better characterize pre-frailty using serum metabolomics in a large cohort of elderly subjects without neurodegenerative diseases. Next, we sought to investigate…Relationship between sleep quality, fear of fall and falls history in people with Parkinson’s disease
Objective: We aimed to investigate the relationship of sleep quality with falls and fear of fall (FOF) in people with Parkinson's disease (PwPD). Background: Fall…Long term effects of Deep Brain Stimulation on Camptocormia in Parkinson’s disease
Objective: Camptocormia (CC) as a syndrome often is a major burden for patients with Parkinson’s Disease (PD). In the absence of response to levodopa (except…Comparative whole transcriptome analysis of human and mice models of Parkinson’s disease bearing defective glucocerebrosidase activity revealed alteration of expression profile of genes involved in the autophagy
Objective: To identify potential biomarkers of Parkinson's disease (PD) associated with dysfunction of enzyme glucocerebrosidase (GCase) by a comparative whole transcriptome analysis of animal models…Single-center experience of deep brain stimulation (DBS) surgery in Malaysia
Objective: We aimed to characterize the DBS cohort and outcomes at a quaternary medical centre in Malaysia. Background: Deep brain stimulation s an established treatment…
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