Design of a Phase 2 Study of Suvecaltamide in Moderate to Severe Parkinson’s Disease Tremor
Objective: Describe the design of a phase 2 study (NCT05642442) of a once-daily, extended-release formulation of suvecaltamide to treat moderate to severe Parkinson’s disease tremor…Differences in EEG spectral features in Alzheimer’s and Parkinson’s disease with mild cognitive impairment
Objective: The aim of this study was to examine changes in brain cortical activity using high-density EEG in subjects with mild cognitive impairment (MCI) due…Reduced non-REM sleep in Parkinson disease is associated with memory impairment and non-motor symptom burden
Objective: To evaluate the relationship between sleep architecture and cognitive function in Parkinson disease (PD). Background: About half of PD patients develop mild cognitive impairment…Risk factors of sleep disordered breathing in Veterans with Parkinson’s disease.
Objective: To investigate factors associated with the risk of sleep disordered breathing (SDB) in Veterans with Parkinson's disease (PD). Background: Sleep disordered breathing is common…The diagnosis value of dopaminergic responsiveness of Parkinson’s disease： a systematic review and meta-analysis
Objective: aimed to confirm the diagnostic value/accuracy of levodopa and/or apomorphine challenge test in parkinsonian syndromes (PDS) to assess their value in the diagnosis of…Integrative brain states facilitate the expression of Parkinson’s tremor
Objective: To test the hypothesis that fluctuations in integrative brain states and/or arousal drive spontaneous fluctuations in PD rest tremor. Background: Parkinson’s disease (PD) rest…Baseline fluid biomarkers in a phase 2 clinical trial in Parkinson’s Disease
Objective: To evaluate baseline CSF and blood-based biomarkers of pathology in early-stage Parkinson’s Disease (PD) participants in the phase 2 clinical trial PASADENA. Background: Observational…PDQ-39 predicts quality of life improvement following neurostimulation for Parkinson’s disease: Prospective observational study
Objective: The primary outcome was assessing QoL of a cohort of patients with PD before and after undergoing DBS surgery, measured using PDQ-39 questionary. Secondary…Detecting clinical fluctuations in chronic biomarker recordings: experiences with chronic subthalamic peak beta band recordings in a large Parkinson’s disease patient cohort
Objective: Since the understanding of electrophysiological biomarker dynamics during every-day activities is crucial for adaptive deep brain stimulation (aDBS), this study aims to investigate characteristics…Subjective cognitive decline as predictor of objective cognitive decline in Parkinson’s patients
Objective: The present study cross-sectionally and longitudinally explores the predictive value of subjective cognitive decline (SCD) regarding objective cognitive decline in a large clinical sample…
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