A pilot, randomized, placebo controlled, double-blinded, delayed start trial of Modafinil for the treatment of Freezing of Gait in Parkinson’s disease.
Objective: To determine if modafinil could improve gait and freezing in people with Parkinson’s disease (PwPD)with freezing of gait (FOG). Background: FOG is a debilitating…Application of multi-parametric diffusion MRI in detecting visual disturbances in advanced Parkinson’s disease population
Objective: We aimed to identify differences in multi-parametric diffusion indices (DTI, NODDI, and DKI) between Parkinson’s disease patients with visual disturbances and those without. Background:…Longitudinal clinical and biomarker characteristics of non-manifest GBA1 N409S carriers: the PPMI cohort
Objective: To examine longitudinal change in clinical characteristics, dopamine transporter (DAT) imaging and biofluid biomarkers in GBA1 N409S non-manifesting carriers (NMCs) versus healthy controls (HCs)…Clinal comprehensive Next-gen gene panel for Parkinson’s Disease
Objective: Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people. There is growing evidence on both gene mutations associated with PD and…Gender differences in non-motor fluctuations in Parkinson’s disease
Objective: To estimate the burden of NMF in PD patients and to evaluate the possible gender effect. Background: Non-motor symptoms (NMS) are commonly experienced by…Identification of potential oxidative biomarkers in saliva of Parkinson’s disease patients
Objective: The goal of this study is to ascertain whether salivary oxidative markers are altered in Parkinson’s Disease (PD) and if there is an association of these markers with disease…Psychometric properties of the Neuropsychiatric Fluctuations Scale: preliminary results in patients with Parkinson’s disease
Objective: To assess the psychometric properties of the Neuropsychiatric Fluctuations Scale (NFS) [1] in patients with Parkinson’s disease (PD) Background: PD presents with non-motor symptoms…Delayed Diagnosis of Hyperthyroidism in Parkinson’s Disease Patient: A Case Report
Objective: To emphasize the importance of thyroid dysfunction as one of the factors that could exacerbate Parkinson's disease (PD) symptoms. Background: Common endocrine disorder associated…Improvement in motor symptoms and quality of life in patients with an earlier stage of advanced Parkinson’s disease treated with foslevodopa/foscarbidopa subcutaneous 24 hour infusion
Objective: To evaluate whether treatment with foslevodopa/foscarbidopa (LDP/CDP), a continuous (24‑hour/day) subcutaneous infusion of carbidopa/levodopa prodrugs, improves motor fluctuations and quality of life (QoL) in…Cholinergic deficits in Parkinson Disease
Objective: To determine whether loss of cholinergic projections to cortical and limbic regions contributes to the development of dementia in Parkinson’s disease (PD). Background: PD…
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