Coordinated Reset Vibrotactile Therapy for the Treatment of Bradykinesia in Parkinson’s Disease Patients
Objective: The present research examines a novel non-invasive vibrotactile device for stimulation of fingertips in a pattern that aims to disrupt pathological physiological beta-band oscillations…Effect of Opicapone and Levodopa on Daily Motor Patterns in Parkinson’s Disease Patients with Early Motor Fluctuations: Findings from the Korean ADOPTION Study
Objective: To evaluate the effect of opicapone (OPC) 50 mg versus an additional 100 mg dose of levodopa (L-DOPA) on ON-/OFF-daily patterns in patients with…AI-Powered Detection of Freezing of Gait Using Wearable Sensor Data in Patients with Parkinson’s Disease
Objective: This study developed a novel patient-independent, cost-effective AI model for detecting Freezing of Gait (FoG), using a single wearable sensor and without the need…A Randomized, Double-Blind, Placebo-Controlled Trial of a Multi-Strain Probiotic for Anxiety in Parkinson’s Disease
Objective: To evaluate the effect of a multi-strain probiotic on anxiety in patients with Parkinson’s disease (PD). Background: There is a lack of dedicated randomized…Comparing Ring and Directional Globus Pallidus Stimulation Effects on Parkinson’s Gait
Objective: This study aims to assess the possible benefits of directional stimulation for motor symptoms in Parkinson’s disease (PD) by comparing therapeutic directional versus ring…Changes in Gut Microbiome of Parkinson’s disease Patients using Photobiomodulation Therapy
Objective: To assess changes in the gut microbiome composition in a small cohort of clinical trial participants using photobiomodulation (light therapy) over a five-year period…Loganic Acid Alleviates the Bidirectional Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
Objective: The study aimed to delineate the molecular mechanism involved in bidirectional olfactory-brain dysfunction through the NLRP3 inflammasome signaling activation in in-vitro and in-vivo model…In Silico Electrophysiology and System Pharmacology Reveal Coupling Between Dopamine Receptors and Ca2+ Channels in Subthalamic Neuronal Cells towards Parkinson’s Disease
Objective: Recent experimental evidence suggests a potential interaction between dopamine D2 receptors (D2R) and N-type Ca2+ channels, impacting the firing patterns of Subthalamic neuronal (STN)…A Preliminary Report on the Clinical Profile of People with PD at an Outpatient Clinic in Malawi
Objective: The objective of the study is to analyze the clinical and socio-demographic characteristics of people with Parkinson`s (PwP) attending the adult neurology outpatient clinic…Characterising early morning akinesia and off (EMO) using Parkinson’s kinetigraph: analysis from a two centre national database in Parkinson’s disease .
Objective: Could wearable sensors such as Parkinson’s kinetograph (PKG) may provide valuable overnight data to detect EMO to augment care in clinic. Background: Early morning…
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