Targeting autophagy to identify novel modulators of Parkinson’s disease using midbrain organoids
Objective: Natural compound libraries are a great source of new chemical molecules that could restore the altered phenotypes in patient derived cells. The objective of…Gray matter volume changes in occipital and temporal visual brain region are associated with freezing of gait in Parkinson’s
Objective: This study aimed to investigate the association of changed gray matter volume(GMV)with Freezing of gait(FOG) in Parkinson’s disease(PD). Background: FOG is a characteristic gait…Epigenome-wide meta-analysis of sex-differential DNA methylation in Parkinson’s disease
Objective: To comprehensively characterize the blood-based DNA methylation alterations related to sex in patients with Parkinson's disease (PD), shedding light on the underlying genes and…Connectomic DBS informed multifocal transcranial direct current stimulation (tDCS) in Parkinson’s Disease: a crossover double blinded study
Objective: To determine if non-invasive neuromodulation of a network previously identified through invasive neuromodulation could improve motor symptoms in Parkinson's disease (PD). Background: A recent…Motor complications in Parkinson’s disease
Objective: To determine the presence, severity, functional impact and predisposing factors of motor complications. Background: Motor complications are well recognized in Parkinson’s disease (PD), but…Design of a Phase 2 Study of Suvecaltamide in Moderate to Severe Parkinson’s Disease Tremor
Objective: Describe the design of a phase 2 study (NCT05642442) of a once-daily, extended-release formulation of suvecaltamide to treat moderate to severe Parkinson’s disease tremor…Differences in EEG spectral features in Alzheimer’s and Parkinson’s disease with mild cognitive impairment
Objective: The aim of this study was to examine changes in brain cortical activity using high-density EEG in subjects with mild cognitive impairment (MCI) due…Reduced non-REM sleep in Parkinson disease is associated with memory impairment and non-motor symptom burden
Objective: To evaluate the relationship between sleep architecture and cognitive function in Parkinson disease (PD). Background: About half of PD patients develop mild cognitive impairment…Risk factors of sleep disordered breathing in Veterans with Parkinson’s disease.
Objective: To investigate factors associated with the risk of sleep disordered breathing (SDB) in Veterans with Parkinson's disease (PD). Background: Sleep disordered breathing is common…The diagnosis value of dopaminergic responsiveness of Parkinson’s disease： a systematic review and meta-analysis
Objective: aimed to confirm the diagnostic value/accuracy of levodopa and/or apomorphine challenge test in parkinsonian syndromes (PDS) to assess their value in the diagnosis of…
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