Contribution of β-band functional connectivity to the α-synuclein propagation in early-stage Parkinson’s Disease: insights from the analysis of brain network properties
Objective: To investigate the relationship between CSF α-synuclein levels and EEG-based network properties, aiming to clarify their role in PD pathophysiology. Background: Parkinson’s disease (PD)…Likelihood to consent within the PREDICT-PD cohort: Identifying potential barriers or promoters of involvement in longitudinal Parkinson’s research
Objective: To establish whether age, gender or years in education influence individual likelihood to consent to Parkinson’s (PD) research. Background: Multiple factors may act as…The Relationship among Depression, Self-Esteem, and Sense of Coherence in Patients with Parkinson’s Disease
Objective: This study aimed to examine the relationship among depression, self-esteem, and sense of coherence (SOC) in patients with Parkinson's disease (PD) and to propose…Modified Timed Up and Go test as a marker for motor improvement in advanced Parkinson’s disease after in-patient multimodal intensive neurorehabilitation and care
Objective: To determine if a modified Timed Up and Go (TUG) test can be used to monitor motor improvement in patients with Parkinson’s disease (PD)…Immediate Impact of Whole-Body Vibration on Backward Walking in Individuals with Parkinson disease
Objective: Determine the immediate impact of performing partial squats using whole-body vibration (WBV) versus level surface on backward walking velocity in People with Parkinson Disease.…Trends on recruitment and retention in Parkinson’s Disease modification trials
Objective: To identify the most common causes of participant’s screen failure (SF) and drop-out (DO) in Phase 2 and 3 Disease Modification Therapy (DMT) trials…A Proof-of-Concept Study of TR-012001, a Nasal Levodopa, in Patients With Parkinson’s Disease With OFF Episodes, Without Dopa Decarboxylase Inhibitor
Objective: To evaluate the safety, tolerability, levodopa pharmacokinetics, and exploratory efficacy of TR-012001 in Parkinson’s disease (PD). Background: TR-012001 is a novel investigational prefilled nasal…LRRK2 Pathway Inhibition By NEU-411, a Potent, Selective, CNS-Penetrant LRRK2 Inhibitor In Healthy Participants
Objective: The aim of this work was to evaluate LRRK2 pathway modulation by the potent, selective, CNS-penetrant LRRK2 inhibitor NEU-411 in healthy adults and elderly…EJS ACT-PD: An Ongoing Initiative to Support Innovation and Sustainability of a Multi-Arm, Multi-Stage Platform Trial for Parkinson’s Disease
Objective: To provide continued consortium expertise to provide ongoing innovation and long-term sustainability in a multi-arm, multi-stage (MAMS) disease modification trial for Parkinson’s disease (PD).…Trans-Spinal Theta Burst Magnetic Stimulation Enhances Treadmill Training Effects on Gait in Parkinson’s Disease
Objective: To investigate whether intermittent Theta Burst Trans Spinal Magnetic Stimulation(iTB–TsMS) enhance treadmill training benefit on gait function, freezing of gait(FoG), other motor symptoms and…
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