Identification of a new Homozygous mutation P.R258Q In the gene SYNJ1 of an Algerian consanguine (inbred) Family suffering from early onset atypical Parkinsonism
Objective: The purpose of this observation is to demonstrate that autosomal recessive early parkinsonism is clinically and genetically heterogeneous Background: Early Onset Parkinson’s disease is…Dissociated longitudinal evolution of limbic serotonergic and striatal dopaminergic and serotonergic pathology in apathetic and non-apathetic patients in early Parkinson’s disease
Objective: To investigate the longitudinal changes in striatal and extra-striatal dopaminergic and serotonergic innervation in apathetic and non-apathetic patients during the five years after the…Motor Function Test Protocol for Parkinsonian Triad in Rodent Model of Parkinson’s Disease
Objective: To review motor deficits protocols and create a set of behavioural protocols that critically address the parkinsonian triad's quantification in Parkinson's disease models. Background:…BILATERAL SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION IN A PATIENT WITH PARKINSON DISEASE AND INTOLERANCE TO STANDARD ANTIPARKINSONIAN DRUGS – A CASE REPORT
Objective: We present a case of a 59-year-old PD patient with severe intolerance to the standard anti-Parkinsonian drugs (APDs) including levodopa (L-DOPA), MAO-B inhibitors, and…Physical activity and cognitive functions in individuals with Parkinson’s disease
Objective: This study aimed to evaluate the relationship between physical activity and cognitive function in PD individuals. Background: Physical activity is positively associated with overall…Tele and video consultations of patients with parkinsonism in the Brazilian public health system – a real life feasibility study
Objective: To evaluate the feasibility and identify obstacles in conducting teleconsultations for patients with parkinsonism in the Brazilian public health system Background: Patients with parkinsonism…Effect of Venglustat by GBA Mutation Severity in Patients With Parkinson’s Disease
Objective: Report outcomes from Part 2 of the phase 2 MOVES-PD trial (NCT02906020) in patients with PD stratified by glucocerebrosidase (GBA) gene mutation severity. Background:…Causes of deaths in patients with Parkinson’s disease in the era before the use of modern drug therapy and at the present time
Objective: to study the impact of modern pharmacotherapy of Parkinson's disease (PD) on the main causes of death. Background: the modern era of the use…Hemiparkinsonism Due to Diencephalic Lesion with 24 Years of Levodopa Response and Only Mild Dyskinesia
Objective: To present a case of a long-standing hemiparkinsonism due to cerebral lesion with a continuous response to a stable dose of levodopa with only…A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson’s disease
Objective: To report the identification of a novel variant in the gene encoding alpha-synuclein (SNCA), segregating with Parkinson’s Disease (PD) in two families of Turkish…
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