ASYMMETRIC EARLY-ONSET PARKINSONISM DUE TO PSEN1 MUTATION
Objective: To report a novel case of early-onset parkinsonism due to a presenilin 1 gene (PSEN1) mutation. Background: Mutations in PSEN1 gene are the most…Development of C-terminal α-Synuclein Vaccine for Treatment and Prevention of Parkinson’s Disease and Other Synucleinopathies
Objective: Prothena is developing active vaccine candidates targeting α-synuclein (α-syn) epitopes shown in clinical and/or preclinical studies to disrupt synuclein pathology. These vaccines, which target…Assessment of cognitive functions and gait in PD and ET patients with pharmacoresistant tremor treated with Gamma Knife thalamotomy.
Objective: The aim of our study was to assess the impact of unilateral Gamma Knife thalamotomy on gait and balance and well as psychological functioning…Alpha-synuclein fibril-based mouse model of REM sleep behavior disorder as a prodrome of synucleinopathy
Objective: To investigate whether in wild-type mice, inoculation of α-synuclein (aSyn) preformed fibrils (PFFs) into the sublaterodorsal tegmental nucleus (SLD), a core structure associated with…Safinamide as an adjunct to Levodopa Therapy in Asian and Caucasian Patients with Parkinson’s Disease and Motor Fluctuations: A post-hoc Analysis of the SETTLE study
Objective: This study evaluated the efficacy and safety outcomes of safinamide as a levodopa adjunct therapy in Asian and Caucasian patients with Parkinson’s disease. Background:…A secretory vesicle failure in Parkinson’s disease occurs in human platelets
Objective: Since platelets use similar, if not the same, mechanisms to accumulate serotonin (5-HT) as dopaminergic neurons to store DA in their VS; we wonder…Vascular Causes of Atypical Parkinsonism Versus Vascular Contribution Towards Atypical Parkinsonism
Objective: In this study, we have compared the clinical features of atypical parkinsonism with high vascular load to find the difference between isolated vascular pathology…CLINICAL AND GENEOLOGICAL FEATURES OF PARKINSON’S DISEASE
Objective: The initial purpose of the work is to study the clinical and genealogical features of Parkinson's disease. Background: Currently, clinical genetics has a number…Preliminary data on multimodal approach for early characterization of Parkinson’s disease (PD) and Multiple System Atrophy (MSA), a prospective study with connected insoles
Objective: Early analysis to evaluate changes in gait parameters as assessed on standardized and ecological conditions and their association to markers of disease progression, i.e.,…Voluntary saccades slowness in parkinson disease and multiple system atrophy
Objective: This study aimed to explore and compare visually-guided and memory-guided saccades in PD and MSA. Background: Parkinson’s disease (PD) produced oculomotor alterations such as…
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