A healthy volunteer phase 1 study of RE-024, a potential phosphopantothenate replacement therapy for patients with pantothenate kinase-associated neurodegeneration (PKAN)
Objective: To assess the safety, tolerability, and pharmacokinetics of single oral doses of RE-024 in healthy adult volunteers. Background: PKAN is a rare, autosomal recessive,…Objectivisation of postural disorders in patients with Parkinson’s disease during the screening stage for DBS
Objective: Objectivisation of degree of postural disorders in PD patients during the screening stage for DBS. Background: The neurosurgical treatment of Parkinson's disease (PD) using…Is inter-limb coupling modified by subthalamic deep brain stimulation and dopaminergic medication in Parkinson’s disease?
Objective: We characterized different aspects of bimanual coordination in patients with PD, including inter-limb coupling, and then determined whether they were altered by therapeutic modulation…Deep brain stimulation in the STN of a Parkinsonian rat model overexpressing human A53T α-synuclein in the substantia nigra – A proof of principle
Objective: To determine if subthalamic nucleus (STN)-deep brain stimulation (DBS) leads to a measurable functional improvement of motor deficits in an AAV1/2 A53T α-synuclein (aSyn)…Is awake intraoperative mapping still necessary for bilateral subthalamic stimulation for Parkinson’s disease in a modern surgical environment?
Objective: To study the impact of the absence of awake clinical evaluation during subthalamic nucleus (STN) deep brain stimulation (DBS) on parameters of stimulation and…Idiopathic delayed-onset edema surrounding deep brain stimulation leads: Insights from a case series and systematic literature review
Objective: We present a multicenter case series of patients with idiopathic delayed-onset edema (IDE) surrounding the deep brain stimulation (DBS) leads, and a systematic literature…Autonomic failure and circadian rhythm of arterial blood pressure in IDIOPATHIC REM behaviour disorders and Parkinson’s disease
Objective: Aim of our study is to correlate the autonomic nervous system failure and circadian rhythm of arterial blood pressure in idiopathic REM behaviour disorders…Vitamin D in early Parkinson’s disease
Objective: To determine serum 25-hydroxy vitamin D (25OHD) concentration at diagnosis and 18 months in incident Parkinson's disease (PD) compared to controls and to investigate…Subjective report does not predict objective swallow impairment in atypical Parkinsonian syndromes
Objective: Swallow and speech disturbances are common in patients with atypical parkinsonism. The emergence of swallowing problems, or dysphagia, is associated with increased morbidity and…Composite autonomic symptom scale-31 (COMPASS-31) is useful for evaluation of autonomic dysfunction in patients with parkinsonism
Objective: To investigate the usefulness of composite autonomic symptom scale 31 (COMPASS-31) in patients with parkinsonism by comparing COMPASS-31 between PD and MSA patients, and…
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