Sensor-based motor state detection in Parkinson’s disease to approach personalized therapy delivery
Objective: As primary objective, we acquire a data pool of medically-treated PD patients with motor fluctuations to determine the sensitivity and specificity of algorithms capable…Strategies to improve drug development efficiency through regulatory interactions, minimizing the placebo effect and improving data integrity within a phase 3 study of tozadenant in Parkinson’s disease patients with motor fluctuations (TOZ-PD)
Objective: To identify and implement strategies to improve the efficiency of drug development in Phase 3 studies. Background: Conducting global clinical trials can be challenging,…“Two odd targets” strategy in deep brain stimulation for Parkinson’s disease with unilateral dystonia
Objective: To describe a patient underwent deep brain stimulation (DBS) with different target in left and right. Background: DBS is a therapeutic option for movement…Clinical characteristics of Parkinson’s disease and essential tremor patients undergoing deep brain stimulation surgery: Five-year data from Columbia University Medical Center (2009 – 2014)
Objective: To compare the clinical characteristics of essential tremor (ET) and Parkinson's disease (PD) patients who underwent deep brain stimulation (DBS) surgery to those of…The effects of 60 Hz frequency of STN-DBS on gait in Parkinson’s disease
Objective: To evaluate the effect of low frequency (60Hz) deep brain stimulation of the subthalamic nucleus (STN-DBS) on gait in patients with Parkinson's disease (PD)…Constant-current stimulation in Parkinson’s disease patients
Objective: To evaluate the clinical effect (motor, non-motor and cognitive) of a three-month switch from constant-voltage (CV) to constant-current (CC) stimulation in Parkinson's disease (PD)…Hand skin temperature and its response to cooling in clinical differentiation of multiple system atrophy and Parkinson’s disease
Objective: To determine the value of testing hand temperature and its response to cooling for differential diagnosis of multiple system atrophy (MSA) versus Parkinson's disease…Comprehensive motor and non-motor staging system in Parkinson’s disease: Results from a global cross-sectional study
Objective: To describe a sample of Parkinson's disease (PD) patients by means of a combined, comprehensive, motor and non-motor staging system. Background: PD severity is…Evaluating the natural history of prodromal PD in the PARS cohort
Objective: An objective of the Parkinson Associated Risk Syndrome (PARS) study is to identify a cohort 'at risk' for Parkinson's disease (PD) using sequential olfactory…Application and correlates of the PSP quality of life scale
Objective: To apply the PSP Quality of Life scale (PSP-QoL) within a cross-sectional PSP population and correlate these scores with those of the PSP rating…
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