The Parkinson progression marker initiative (PPMI) – Developing a comprehensive longitudinal biomarker dataset
Objective: The goal of the Parkinson Progression Marker Initiative (PPMI) is to identify clinical, imaging and biospecimen biomarkers of PD progression to provide tools for…The systemic synuclein sampling study (S4)
Objective: The Systemic Synuclein Sampling Study (S4) is designed to characterize the distribution of alpha-synuclein (α-syn) pathology in multiple tissues and biofluids in Parkinson's disease…Can intraoperative clinical testing really predict the effects of deep brain stimulation in the subthalamic nucleus?
Objective: To evaluate whether stimulation-induced therapeutic and side effects of the permanent electrode are predictable by intraoperative test stimulation with clinical examination. Background: Intraoperative test…Stimulation of the globus pallidus internus in the treatment of Parkinson’s disease: Long-term results of a monocentric follow-up
Objective: To investigate the long-term outcome of pallidal deep brain stimulation (GPi-DBS) in Parkinson's disease (PD). Background: GPi-DBS is beneficial in patients with advanced levodopa-responsive…The effect of short pulse width neurostimulation in GPi-DBS
Objective: To evaluate (1) clinical usefulness and (2) adverse effects of thirty microseconds pulse width stimulation in deep brain stimulation of the globus pallidus internus…Variability in the ideal target of GPi DBS for Parkinson’s disease requires advanced direct targeting for optimal results
Objective: Our findings have the potential to transform the clinical practice of surgeons who rely solely on indirect targeting, by raising awareness of the anatomic…Could tonic chin electromyogram density be a potential marker for differentiating atypical Parkinsonian syndromes from Parkinson’s disease among alpha-synucleinopathies?
Objective: The study aimed to examine whether the video-polysomnography (vPSG) could provide some clues for differentiating atypical Parkinsonian syndromes (APS) from Parkinson's disease (PD) among…Impulse control disorder associates with tyrosine hydroxylase 2 gene variants in Parkinson’s disease patients subject to dopaminergic therapy
Objective: The aim of this study was to identify novel genetic variants associated with Impulse control disorder (ICD) manifestation in PD patients subject to dopaminergic…A cross-sectional study of sensor-based gait analysis in atypical Parkinsonian disorders
Objective: Primary objective was to identify quantitative markers of gait impairment in patients with idiopathic Parkinson's disease (IPD), atypical Parkinsonian disorders (APD) and healthy controls…Loss of FBXO7 (PARK15) leads to disturbances in proteasomal function and models parkinsonism-like and pyramidal symptoms in mice
Objective: To model Parkinsonian-pyramidal syndrome (PARK15) in mice and investigate the impact of loss of F-box only protein 7 (FBXO7) in neurons on proteasomal activity.…
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