Impact of subclinical apathy prior to deep brain stimulation on the quality of life of patients with Parkinson’s disease
Objective: To evaluate the influence of pretreatment subclinical apathy on patient QOL following subthalamic nucleus DBS (STN-DBS) in PD patients 12 months after surgery. Background:…The social value of improvement in activities of daily living from levodopa-carbidopa intestinal gel use among the advanced Parkinson’s disease population
Objective: Quantify the value of improvement in functional status (FS) measured as activities of daily living (ADL) limitations, from levodopa-carbidopa intestinal gel (LCIG) use among…mPower: A smartphone-based study of Parkinson’s disease provides personalized measures of disease impact
Objective: mPower is a clinical observational study of Parkinson's disease (PD) conducted completely through an iPhone app focused on the ability of mobile devices and…Reduced lifespan and climbing ability observed in the overexpressing human α-synuclein without heat shock protein CNB115 in Parkinson’s disease drosophila line
Objective: To investigate the neurotoxic role of overexpressing α-synuclein without Heat Shock Protein CNB115 (HSP115) in Parkinson's disease Drosophila line. Background: Parkinson's disease (PD) is…Clinical exome sequencing – diagnostic yield in a sample of German patients with Parkinson’s disease
Objective: To assess the diagnostic yield of clinical exome sequencing (CES) in individuals with Parkinson's disease (PD) seen in a specialized movement disorder clinic. Background:…Two-step induction of dopaminergic neurons – Differentiation of leukapharesis-derived mesenchymal stem cells
Objective: The aim of the present study is to establish a reproducible in-vitro protocol to induce the human MSCs derived from peripheral blood, after mobilization…IL-6 and motor symptoms in Parkinson’s disease
Objective: To assess the concentration of interleukin-6 (IL-6) in serum of patients with PD and its relation to motor symptoms. Background: Participation of inflammatory mechanisms…LC3 deacetylation by SIRT1 is involved in neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson’s disease
Objective: Our previous study has demonstrated that resveratrol (RV) enhanced clearance of misfolded α-synuclein proteins in cellular models of PD, with the activation of SIRT1…Involvement of peripheral immune system in the pathogenesis of Parkinson’s disease
Objective: To investigate the role of peripheral immune system in the pathogenesis of Parkinson's disease carrying LRRK2 risk variants. Background: Leucine-rich repeat kinase 2 (LRRK2)…Oral apomorphine film (APL-130277) produces no buccal mucosal irritation: Results of a toxicological study
Objective: Determine the tolerance of and potential for cheek pouch buccal mucosa irritation following the administration of apomorphine film (APL-130277). Background: APL-130277 is a sublingual…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.