Neural mechanisms underlying step initiation failure in patients with Parkinson’s disease and freezing of gait
Objective: To investigate the neural mechanisms underlying gait initiation failure in Parkinson's disease patients with Freezing of Gait. Background: Freezing of Gait (FOG) is a…Movement related beta oscillatory activity during self-paced wrist movement in the human subthalamic nucleus
Objective: To explore voluntary movement related neuronal activity in the subthalamic nucleus in patients with Parkinson's disease (PD). Background: How the human basal ganglia processes…Increased cortical control of gait in patients with Parkinson’s disease and freezing of gait
Objective: To determine structural connectivity between the mesencephalic locomotor region (MLR) and the supplementary motor area (SMA) in freezers compared to non-freezers. Background: Freezing of…Spectral analysis of rapid eye movement (REM) sleep as a potential marker of neurodegenerative disease in REM sleep behavior disorder
Objective: To investigate whether spectral analysis at baseline in rapid eye movement (REM) sleep can differentiate patients with REM sleep behavior disorder (RBD) who will…Catechol-o-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson’s disease
Objective: The Catechol-O-Methyltransferase (COMT) Val158Met polymorphism has been proposed to be associated with increased risk of PD and have a specific impact on dopamine-mediated prefrontal…Longterm outcome of cognition following subthalamic deep brain stimulation in Parkinson´s disease
Objective: Longterm, “real-life” assessment of cognitive evolution following subthalamic (STN) deep brain stimulation (DBS) in patients suffering from Parkinson´s disease. Background: Anecdotal reports have speculated…Impaired cube copy on the MOCA indicates worse performance in several cognitive domains in Parkinson´s disease
Objective: We aimed to identify if an impairment of the cube copy of the Montreal Cognitive assessment (MoCA) was associated with worse cognitive status in…Viewer responses to a virtual reality simulation of Parkinson’s disease psychosis
Objective: To examine the accuracy, effectiveness, and utility of a novel virtual reality (VR) simulation representing symptoms of Parkinson's disease psychosis (PDP). Background: Diagnosing PDP…GAITRite comparison between Parkinson’s disease stages
Objective: To compare gait performance across Parkinson's disease stages. Background: Parkinson's disease (PD) is characterized with changes in locomotion and posture, which are associated with…Gender and age-based differential item functioning (DIF) analysis of MDS-UPDRS
Objective: Test if DIF due to gender or age is present in MDS-UPDRS items. Background: Testing a rating scale for DIF is a core step…
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