Exercise-induced adaptive neuroplasticity in the MPTP mouse model of Parkinson’s disease
Objective: To increase our understanding of how physical exercise may drive adaptive neuroplasticity in a mouse model of Parkinson's disease (PD). Background: PD is a…The Parkinson progression marker initiative (PPMI) – Developing a comprehensive longitudinal biomarker dataset
Objective: The goal of the Parkinson Progression Marker Initiative (PPMI) is to identify clinical, imaging and biospecimen biomarkers of PD progression to provide tools for…The systemic synuclein sampling study (S4)
Objective: The Systemic Synuclein Sampling Study (S4) is designed to characterize the distribution of alpha-synuclein (α-syn) pathology in multiple tissues and biofluids in Parkinson's disease…Can intraoperative clinical testing really predict the effects of deep brain stimulation in the subthalamic nucleus?
Objective: To evaluate whether stimulation-induced therapeutic and side effects of the permanent electrode are predictable by intraoperative test stimulation with clinical examination. Background: Intraoperative test…Electric stimulation of the nucleus subthalamicus is able to modulate prepulse inhibition. A pilot study in Parkinson´s disease
Objective: To evaluate if prepulse inhibition (PPI) is influenced by electrical stimulation in the Nucleus subthalamicus (STN) of patients with Parkinson´s disease (PD). Background: PPI…Speech 10 years post bilateral STN-DBS for Parkinson’s disease
Objective: This study reports on the type and severity of speech problems up to 10 years after bilateral deep brain stimulation (DBS) of the subthalamic…DBS of the STN in 44 patients with Parkinson’s disease – Radiological and clinical outcome
Objective: Precision in implantation of deep brain stimulation (DBS) electrodes relies on systematic interdisciplinary planning and intra-operative testing and needs to be discussed along with…Apraxia of speech as the initial manifestation of progressive supranuclear palsy
Objective: We report a patient with apraxia of speech as the initial symptom who finally developed a progressive supranuclear palsy. Background: Progressive supranuclear palsy (PSP)…Association analysis of SNP rs11868035 in SREBF1 with Parkinson’s disease, amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population
Objective: To examine the possible genetic association of rs11868035 with Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA) in a Chinese…Clinical and polysomnographic features correlates to sleep-disordered breathing in multiple system atrophy
Objective: The purpose of this study is to elucidate whether sleep-discorded breathing (SDB) impact motor and non-motor symptoms in multiple system atrophy (MSA), and to…
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